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This study investigated the day-to-day variability of daily physical activity and its effect on sleep and mood in a longitudinal within-subjects study for 7 days and 6 nights.

Materials and methods

Healthy office employees aged 25–35 years with a sedentary lifestyle participated in the study. Seven-day sleep diaries were used to evaluate sleep patterns. Ten-point scales were used to measure the level of happiness and stress. Daily physical activity was measured in steps/day using pedometers. Two hundred forty-five steps/day scores and changes induced in sleep and mood were analysed.


There is a relationship between daily physical activity and sleep/mood. An inverted U-shaped relationship may be assumed between sleep duration, sleep quality, feelings after waking up, and the number of steps/day. Increasing the number of steps/day decreases the level of stress and daytime sleepiness and increases sleep efficiency. Sleep efficiency/daytime sleepiness and sleep duration did not show any association.


Based on the results, after a physically exhausting day, decreased stress and improved sleep efficiency may be experienced, while sleep duration may decrease, which may reduce the participants’ motivation to develop an active lifestyle. For further studies, it would be crucial to use individual exercise intervention programmes to reinforce the positive effects of exercise on sleep and/or mood.

Open access
Physiology International
Authors: Zs. Sári, T. Kovács, T. Csonka, M. Török, É. Sebő, J. Toth, D. Tóth, E. Mikó, B. Kiss, D. Szeőcs, K. Uray, Zs. Karányi, I. Kovács, G. Méhes, P. Árkosy and P. Bai


Breast cancer is characterized by oncobiosis, the abnormal composition of the microbiome in neoplastic diseases. The biosynthetic capacity of the oncobiotic flora in breast cancer is suppressed, as suggested by metagenomic studies. The microbiome synthesizes a set of cytostatic and antimetastatic metabolites that are downregulated in breast cancer, including cadaverine, a microbiome metabolite with cytostatic properties. We set out to assess how the protein expression of constitutive lysine decarboxylase (LdcC), a key enzyme for cadaverine production, changes in the feces of human breast cancer patients (n = 35). We found that the fecal expression of Escherichia coli LdcC is downregulated in lobular cases as compared to invasive carcinoma of no special type (NST) cases. Lobular breast carcinoma is characterized by low or absent expression of E-cadherin. Fecal E. coli LdcC protein expression is downregulated in E-cadherin negative breast cancer cases as compared to positive ones. Receiver operating characteristic (ROC) analysis of LdcC expression in lobular and NST cases revealed that fecal E. coli LdcC protein expression might have predictive values. These data suggest that the oncobiotic transformation of the microbiome indeed leads to the downregulation of the production of cytostatic and antimetastatic metabolites. In E-cadherin negative lobular carcinoma that has a higher potential for metastasis formation, the protein levels of enzymes producing antimetastatic metabolites are downregulated. This finding represents a new route that renders lobular cases permissive for metastasis formation. Furthermore, our findings underline the role of oncobiosis in regulating metastasis formation in breast cancer.

Open access