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, and psilocybin are serotonergic hallucinogens that operate primarily on the 5-hydroxytryptamine 2A receptors (5-HT 2A ), in the brain ( Nichols, 2016 ). Substances like the dissociative ketamine, entactogens such as MDMA, and polydrug admixtures such
Psychedelic drugs such as psilocybin and lysergic acid diethylamide (LSD) as well as related compounds (e.g., 3,4-Methylenedioxymethamphetamine; MDMA) have preliminarily demonstrated a high level of safety and efficacy for treating psychiatric
psychedelic research, popularizing of use of non-ordinary states of consciousness to aid in PTSD, anxiety and depression, end of life and a growing sense that the use of substances like MDMA, psilocybin and others may become mainstream approaches to treating
mental health conditions, including: ayahuasca for addiction (e.g., Fábregas, González, Fondevila, & et al, 2010 ; Loizaga-Velder & Verres, 2014 ); MDMA for PTSD (e.g., Chabrol, 2013 ; Feduccia et al., 2018 ; Gorman et al., 2020 ; Mithoefer et
: psilocybin in the treatment of depressive disorders and 3,4-methylenedioxymethamphetamine (MDMA) in the treatment of post-traumatic stress disorder (PTSD; For the purposes of this commentary, MDMA is considered a psychedelic – not only as a cultural or a
-classic” (e.g., 3,4-methylenedioxymethamphetamine (MDMA). Classic psychedelics act at the serotonin 2A receptor (5-HT 2A R) as agonists or partial agonists ( Johnson, Hendricks, Barrett, & Griffiths, 2019 ), and the psychological mechanisms for non
.1080/02791072.2015.1094156 Buffum , J. , & Moser , C. ( 1986 ). MDMA and human sexual function . Journal of Psychoactive Drugs, 18 ( 4 ), 355 – 359 . doi: 10
. Question on prevalence asked whether respondents have played games under the influence of following substances once, repeatedly, or never in the last 12 months: caffeine, tobacco, alcohol, cannabis or cannabis resin, amphetamine or methamphetamine, Ecstasy/MDMA
their mental health. When asked about their use of other psychoactive substances, 64% had used psilocybin, 45% had used MDMA, and 32% had used LSD at least once. Participants who reported using these drugs commonly stated that they used them to support
occasionally, a few times per year”) and 3,4-methylenedioxymethamphetamine (MDMA or ecstasy ) (“occasionally, but for a year I have used it several times, every 2–3 months, in the weekends”), and had been a daily cannabis smoker for the preceding 8 years. Ms
