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Psychedelic drugs such as psilocybin and lysergic acid diethylamide (LSD) as well as related compounds (e.g., 3,4-Methyl​enedioxy​methamphetamine; MDMA) have preliminarily demonstrated a high level of safety and efficacy for treating psychiatric

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psychedelic research, popularizing of use of non-ordinary states of consciousness to aid in PTSD, anxiety and depression, end of life and a growing sense that the use of substances like MDMA, psilocybin and others may become mainstream approaches to treating

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: psilocybin in the treatment of depressive disorders and 3,4-methylenedioxymethamphetamine (MDMA) in the treatment of post-traumatic stress disorder (PTSD; For the purposes of this commentary, MDMA is considered a psychedelic – not only as a cultural or a

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Journal of Psychedelic Studies
Authors:
Stacey B. Armstrong
,
Adam W. Levin
,
Yitong Xin
,
Jordan C. Horan
,
Jason Luoma
,
Paul Nagib
,
Brian Pilecki
, and
Alan K. Davis

-classic” (e.g., 3,4-methylenedioxymethamphetamine (MDMA). Classic psychedelics act at the serotonin 2A receptor (5-HT 2A R) as agonists or partial agonists ( Johnson, Hendricks, Barrett, & Griffiths, 2019 ), and the psychological mechanisms for non

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.1080/02791072.2015.1094156 Buffum , J. , & Moser , C. ( 1986 ). MDMA and human sexual function . Journal of Psychoactive Drugs, 18 ( 4 ), 355 – 359 . doi: 10.1080/02791072.1986.10472369 10

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. Question on prevalence asked whether respondents have played games under the influence of following substances once, repeatedly, or never in the last 12 months: caffeine, tobacco, alcohol, cannabis or cannabis resin, amphetamine or methamphetamine, Ecstasy/MDMA

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occasionally, a few times per year”) and 3,4-methylenedioxymethamphetamine (MDMA or ecstasy ) (“occasionally, but for a year I have used it several times, every 2–3 months, in the weekends”), and had been a daily cannabis smoker for the preceding 8 years. Ms

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their mental health. When asked about their use of other psychoactive substances, 64% had used psilocybin, 45% had used MDMA, and 32% had used LSD at least once. Participants who reported using these drugs commonly stated that they used them to support

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Psychedelic-Assisted Therapies (PATs). The most empirically substantiated PAT for trauma incorporates an 18-session protocol that uses MDMA as the active agent in up to three separate sessions ( Mitchell et al., 2023 ). In addition, preliminary studies offer

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decriminalization, groundbreaking legalization of therapeutic psilocybin, pending approval of MDMA for Post-Traumatic Stress Disorder (2003), and bills in progress legalizing personal possession and use, the expansion of psychotherapeutic approaches and applications

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