Search Results
1/2 z h 6.2 ± 2.0 7.0 ± 5.9 CL z/F L/h/kg 2.9 ± 0.5 35.1 ± 12
2.5 ± 1.4 7.8 ± 3.5 t 1/2 z h 6.2 ± 4.8 6.7 ± 3
7 days 12.92 1.81 12.28 −7.05 9.55 −6.54 Room temperature for 15 h
.128 ± 0.4 4.3 MRT (0-∞) h 9.316 ± 0.55 5.9 t 1/2 z h 4.149 ± 0.92 22.2 T max h 6 ± 0 0 Vz/F L kg −1 2.797 ± 0.64 22.9 CLz/F L h −1 kg −1 0.468 ± 0.05 10.5 C max ug L −1 1,879.1 ± 340.72 18.1 Conclusion A reliable and high-throughput UPLC-MS/MS method was
and noscapine in rat plasma are shown in Fig. 3 . The half-lives ( t 1/2z ) of papaverine and noscapine in the rats after intravenous administration were 1.0 ± 0.2 h, 6.2 ± 2.2 h, respectively, while the t 1/2z after oral administration were 2.4 ± 0
-BUTINACA after oral administration ( n = 6) Parameters Unit Oral AUC (0-t) ng mL −1 *h 2923.0 ± 523.5 AUC (0-∞) ng mL −1 *h 3004.2 ± 570.4 MRT (0-t) h 6.3 ± 0.7 MRT (0-∞) h 7.1 ± 0.8 t 1/2z h 4.4 ± 1.1 T max h 2.8 ± 0.5 C max ng mL −1 616.9 ± 154.5 AUC (0-t
138 C₇H₆O₃ 137, 109, 93 Salicylic acid Phenolic acids
fragment ion m/z 177.0187 [M−H−C 6 H 6 O] − and m/z 151.0054 [M−H−C 8 H 8 O] − , the latter was further cleaved to produce −MS 3 fragment ion m/z 133.0277 [M−H−C 8 H 8 O−H 2 O] − and −MS 2 fragment ion m/z 125.0267 [M−H−C 8 H 8 O−CO] − , −MS 3
at m/z 551.75, 578.10, and 527.75 due to [M–C 2 H 5 N–CH 3 –H] + , [M–OCH 3 ] + and [M–2C 2 H 6 N 2 ] + respectively. Furthermore, fragments were observed at 499.65 and 465.00 due to the loss of two and one CH 3 radical. The ion at m/z 188 was
.045 [M−H] − Aromaticity 32 Gallic acid C 7 H 6 O 5 LNTHITQWFMADLM-UHFFFAOYSA-N 2.77 169.0144344 169.014 [M−H] − Phenols 33 Cryptochlorogenic acid C 16 H 18 O 9 GYFFKZTYYAFCTR-AVXJPILUSA-N 3.16 353.0880346 353.088 [M−H] − Phenylpropanoids 34 2
