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1951 1960 A randomized trial of beta-blockade in heart failure. The Cardiac Insufficiency Bisoprolol Study (CIBIS). CIBIS Investigators and Committees. Circulation, 1994, 90, 1765

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The new analytical method of very high pressure liquid chromatography (VHPLC) has been designed for the estimation of related substances in bisoprolol fumarate. Several columns filled with sub-2-μm totally porous and shell adsorbent have been tested and compared during the method development. The columns' resolution was investigated. The shell adsorbent appears to have smaller resolution than the totally porous adsorbent. The tips and recommendations for the HPLC-VHPLC method transfer are presented. Significant reduction in analysis run time and solvent consumption has been obtained.

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-blocker Pindolol 20–150 9.54 1.83 Carazolol < 15 9.52 3.73 Bisoprolol

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Hypertension Society’s PATHWAY Studies Group: Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover

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study, and this is probably because of the difference between metoprolol and propranolol with metoral. Another research by Sleilaty et al. [ 26 ] compared the effects of amiodarone and bisoprolol in reducing the occurrence frequency of post-CABG AF

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Orvosi Hetilap
Authors: Kristóf Rácz, Tamás Tiszai-Szűcs, János Gál, and Miklós Kertai D.

Poldermans, D., Boersma, E., Bax, J. J. és mtsai: The effect of bisoprolol on perioperative mortality and myocardial infarction in high-risk patients undergoing vascular surgery. Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress

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