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Introduction Pituitary adenylate cyclase-activating polypeptide (PACAP or ADCYAP) was isolated from sheep’s hypothalami and characterized by Miyata et al. ( 1989 , 1990 ). It was named on its ability to stimulate adenylate

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European Journal of Microbiology and Immunology
Authors: Markus M. Heimesaat, Gernot Reifenberger, Viktoria Vicena, Anita Illes, Gabriella Horvath, Andrea Tamas, Balazs D. Fulop, Stefan Bereswill, and Dora Reglodi

functions . Pharmacol Rev 52 , 269 – 324 ( 2000 ) 3. Gomariz RP , Juarranz Y , Abad C , Arranz A , Leceta J , Martinez C : VIP-PACAP system

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Introduction Pituitary adenylate cyclase activating polypeptide (PACAP) was first isolated from ovine hypothalamic extracts. Based on the structural homology (68%) of its N-terminal amino acid sequence with the vasoactive intestinal peptide (VIP) it

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. PACAP in immunity and inflammation. Ann New York Acad Sci. 2003; 992: 141–157. 37 Arranz A, Abad C, Juarranz Y, et al. Vasoactive intestinal peptide

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E , Jungling A , Tamas A , Juhasz T , . PACAP deficiency as a model of aging . Geroscience 2018 ; 40 ( 5–6 ): 437 – 52 , https://doi.org/10.1007/s11357-018-0045-8 . 10.1007/s11357-018-0045-8 38. Reglodi D , Kiss P , Tamas A

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microbiota changes in mice lacking pituitary adenylate cyclase activating polypeptide (PACAP) — bifidobacteria make the difference . Eur J Microbiol Immunol . 2017 ; 7 : 187 – 99 . 10.1556/1886.2017.00021 28

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