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prognosis for victims, the prophylactic drug or immediate post-exposure administration of an efficient antidote would be imperative. Unfortunately, the effectiveness of current treatment protocols is unpredictable due to the weak effect of atropine on the

Open access
Acta Chromatographica
Authors: S.M. Nurulain, S. Ojha, S. Dhanasekaran, K. Kuča, N. Nalin, C. Sharma, A. Adem, and H. Kalász

Distribution of K027, a hydrophilic, positively charged compound is monitored in the body of pregnant mice using high-performance liquid chromatography (HPLC). Intraperitoneal injection was done on the 18th day of pregnancy; the plasma and brains of the mother mice, placentae and the fetuses’ brains were dissected following 5, 15, 30, 60, and 120 min of treatment. Significant incorporation of K027 was found in the placentae and in fetuses’ brains relative to its levels in the mothers’ plasma and brains. This incorporation warns of a possible adjustment of dose of pyridinium aldoxime antidotes in case of pregnancy. Further studies with different gestational periods and animal models are warranted.

Open access
Acta Chromatographica
Authors: Shuanghu Wang, Zixia Lin, Ke Su, Jing Zhang, Lijing Zhang, Zhimou Gao, Zhiyi Wang, Jianshe Ma, and Xianqin Wang

mL can result in human beings' moderately severe poisoning whose rate of death is as high as over 50% [ 5 , 6 ]. The research for the antidote to the paraquat is of great importance. As non-selective herbicide, it has been applied to agriculture in

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typically used clinically as an antidote to treat patients poisoned by ARs, subsequent to accidental or intended exposures (i.e., suicide attempts, or poisoning of others [ 3 ]. In this context, a rapid analytical method would be invaluable to confirm a

Open access