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natural compounds for their antimicrobial properties either alone or in synergy with already established antibiotics. Capsaicin The capsaicinoid capsaicin (8-methyl- N -vanillyl-6-nonenamide) is an alkaloid that is produced at variable concentrations by

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Capsaicin has been reported to exhibit an inhibitory effect on the P-glycoprotein (P-gp) function in vitro. To investigate its concentration-dependent effect in vivo, a sensitive assay that can characterize the absorption and disposition of capsaicin needs to be developed. This study reports the development of a sensitive LC-MS/MS assay for the determination of capsaicin in mouse plasma. The sample pretreatment involved a one-step extraction of 20 μL plasma with t-butyl methyl ether. Separations were achieved on a C18 column and the detection was performed on an LC-ESI-MS/MS by multiple reaction monitoring. The assay was linear over a wide concentration range from 0.325 to 650 ng mL−1 (r > 0.999), with a LLOQ of 0.325 ng mL−1. The developed method was applied to i.v. (dose 0.325 and 0.65 mg kg) and oral absorption (dose 40 mg kg) studies in mice. After i.v. injection, the t 1/2,λz, V z and CL s ranged from 0.13–0.16 h, 127.6–141.8 mL, and 547.3–775.4 mL/h, respectively. After oral administration, a secondary peak was observed and the terminal half-life was prolonged (1.51 h). Capsaicin was poorly absorbed, with the absolute oral bioavailability (F) ranging from 1.02% to 1.56%. The developed assay may be useful in studies where sample volumes are limited.

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detection at 255 nm. The capsaicin and dihydrocapsaicin content was determined on the basis of a standard solution of capsaicin containing also dihydrocapsaicin (Merck). Analysis of Antioxidant Activities. Antioxidant

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Szolcsányi, J., Barthó, L.: Capsaicin-sensitive afferents and their role in gastroprotection: an update. J. Physiol. Paris, 2001, 95 , 181–188. Barthó L. Capsaicin

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A neurogén húgyhólyag klinikuma és terápiás lehetőségei

Clinical aspects and therapeutic possibilities of neurogenic bladder

Orvosi Hetilap
Authors: Péter Járomi, Tamás Banyó, Mihály Boros, Ferenc Papp, and Andrea Szabó

: 19084–19089. 27 Maggi CA, Santicioli P, Giuliani S, et al. The capsaicin-sensitive innervation of the rat urinary bladder: further studies on mechanisms regulating

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functions of capsaicin sensory nerve endings involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Neuroscience 1988; 24: 739–768. 8

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.: Brainstem neuropeptides and vagal protection of the gastric mucosal against injury: role of prostaglandins, nitric oxide and calcitonin-gene related peptide in capsaicin afferents. Curr. Med. Chem., 2012

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Physiology International
Authors: N. Almási, Z. Murlasits, A. Al-awar, Á. Csonka, S. Dvorácskó, C. Tömböly, S. Török, D. Bester, A. Pósa, C. Varga, and K. Kupai

capsaicin in mouse large intestine: high abundance and sensitivity in rectum and distal colon . Am J Physiol Gastrointest Liver Physiol 2009 ; 297 ( 2 ): G348 – 60 . . PubMed PMID: 19497956 . 10.1152/ajpgi

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