Authors:Daniel Blanco-Ania and Floris P. J. T. Rutjes
be used for virtually any chemical reaction and are therefore cost efficient to operate. Nevertheless, since two decades or so, continuous-flowchemistry has become more widespread in academic synthetic chemistry groups that recognized the benefits of
In this section of the journal, the continuous-flow chemistry literature of the preceding months is presented. Included are articles published in the period October–December 2013 and January–March 2014. Some key examples are highlighted in the form of graphical abstracts. The remaining publications in the field are then listed ordered by journal name, with review articles grouped at the end.
In this section of the journal, the continuous flow chemistry literature of the preceding months is presented. Included are articles published in January and February 2012 and some articles from 2011 which received page numbers only in the beginning of 2012. Some key examples are highlighted in the form of graphical abstracts. The remaining publications in the field are then listed ordered by journal name, with review articles grouped at the end.
Authors:Dong-Hyeon Ko, Ki-Won Gyak and Dong-Pyo Kim
system integration and process diversification have greatly enhanced the system performance for continuous-flowchemistry [ 3 ].
Among the microfluidic components, microreaction modules and microseparation units are the major components that can
of continuous-flowchemistry in nearly all aspects of chemical synthesis [ 10 – 12 ]. Adaptation of syntheses of many active pharmaceutical ingredients (APIs) and drugs to continuous flow have also been reviewed extensively and will not be covered in
Authors:Gregory A. Price, Debasis Mallik and Michael G. Organ
continuous-flowchemistry from a cutting-edge research science to an alternative production platform for industrial applications. The objectives can be summarized in 5 steps:
Development of on-line, in-line, and at-line measurement tools to improve
continuous-flowchemistry, inline analytics, and automation technology has shown great potential to gather accurate reaction data [ 36 ]. Such integrated systems allow to reduce the total optimization time and the required amount of material. Recently, Jensen
Authors:Gellért Sipos, Tamás Bihari, Dorottya Milánkovich and Ferenc Darvas
[ 24 ]. If we accept (as we frequently do during the daily work in the laboratory) that extractions are chemical processes, then we can consider the ISSpresso as an archetypal continuous-flowchemistry instrument [ 25 ]. In this, the water is fed into