for the generation of very reactive reagents [ 28 ]. Some of these reagents, such as diazomethane (CH 2 N 2 ), ethyl diazoacetate, carbon monoxide (CO), hydrogen cyanide (HCN), and isocyanides, are normally used only reluctantly or are entirely banned
ketone was obtained on a 3-step continuous protocol affording the desired product in high yield and purity, where the key step was the diazomethane reaction using the tube-in-tube technology followed by acidic quench [ 10 ].
Authors:Bartholomäus Pieber, Kerry Gilmore and Peter H. Seeberger
, called “generators,” are one of the strengths of flow chemistry, allowing for safe access to reagents which are usually avoided or even deemed “forbidden” such as diazomethane [ 10 ], chlorine [ 11 , 12 ], singlet oxygen [ 13 – 16 ], ozone [ 17 – 20