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Interventional Medicine and Applied Science
Authors:
Kourosh Shahraki
,
Mohammad Naeim Amini Fard
,
Farkhondeh Shahri
,
Rama Pourmatin
,
Tafgeh Mohammadi
,
Paria Ghasemi Boroumand
, and
Kianoush Shahraki

cefotaxime on the human corneal endothelium . J Cataract Refract Surg 27 , 250 – 255 ( 2001 ) 10.1016/S0886-3350(00)00474-0 18. Matsuura K

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Orvosi Hetilap
Authors:
Annamária Szénási
,
Gabriella Dörnyei
,
Anita Rácz
,
Béla Debreczeni
, and
Ákos Koller

Eskinder, H., Harder, D. R., Lombard, J. H.: Role of the vascular endothelium in regulating the response of small arteries of the dog kidney to transmural pressure elevation and reduced PO 2 . Circ. Res

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administration of statins. Since its discovery in the 1980s, nitric oxide is in fact the elusive endothelium-derived relaxing factor, it has become evident that nitric oxide is not only a major cardiovascular signaling molecule, but changes in its

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Oberleithner H, Peters W, Kusche-Vihrog K, et al. Salt overload damages the glycocalyx sodium barrier of vascular endothelium. Pflugers Arch. 2011; 462: 519–528. 38 Kusche-Vihrog K

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Szaruhártya-átültetés a 21. század elején

Corneal transplantation at the beginning of the 21th century

Orvosi Hetilap
Authors:
László Módis
,
Miklós Lukács
, and
Sára Makhoul

–428. 24 Patel SV, Hodge DO, Bourne WM. Corneal endothelium and postoperative outcomes 15 years after penetrating keratoplasty. Am J Ophthalmol. 2005; 139: 311

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2007 14 91 95 Nicolaides, A. N.: Chronic venous disease and the leukocyte-endothelium interaction: From

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The first 60-min phase of inflammatory ascites formation was studied by intraperitoneally (i.p.) administered macromolecular inducers: yeast cell wall zymosan binds to specific macrophage receptors, polyethyleneimine (PEI) and concanavalin A (ConA), produces non-covalent cross-links on the surface of various cells, while λ-carrageenan may function as a contact activator. Depletion of peritoneal macrophages was performed by overnight pretreatment with diphtheria toxin in transgenic mice, resulting in a significant (p < 0.01) decrease in the induced formation of ascitic fluid. It was shown that induced ascites is mediated partly (PEI, ConA, and carrageenan) or completely (zymosan) by peritoneal macrophages. Inhibition of prostanoid synthesis with indomethacine or of the kallikrein/bradykinin system with aprotinin also produced a significant (p < 0.01) but incomplete inhibition. A slight additivity occurred between the different inhibitory effects. In another series of experiments, the i.p. administration of bradykinin (without a macromolecular inducer) also produced marked ascites, which was not affected by macrophage depletion. The origin of the macrophage-independent part of the induced ascites is best explained by the deformation of the mesothelial cell surface, resulting in signal transfer to the underlying endothelium and the passage of ascitic fluid in the opposite direction. The soluble mediators are represented by prostanoids, bradykinin and other, unidentified agonists.

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Interventional Medicine and Applied Science
Authors:
Pietro Giudice
,
Tiziana Attisano
,
Marco Di Maio
,
Elisabetta Bellino
,
Maria Polito
,
Cesare Baldi
,
Francesco Vigorito
,
Michele Di Muro
,
Salvatore Tomasello
,
Alfredo Galassi
, and
Federico Piscione

Hamilos M, Sarma J, Ostojic M, Cuisset T, Sarno G, Melikian N, Ntalianis A, Muller O, Barbato E, Beleslin B, Sagic D, De Bruyne B, Bartunek J, Wijns W: Interference of drug-eluting stents with endothelium

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reduced speed. Endothelial dysfunction is considered as the most important factor in the pathogenesis of CSF [ 1 ]. The impairment of endothelium function is the earliest marker that indicates coronary artery disease. In many studies, the deterioration of

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Pseudoxanthoma elasticumban szenvedő betegek multidiszciplináris ellátása

Multidisciplinary management of patients affected with pseudoxanthoma elasticum

Orvosi Hetilap
Authors:
Klára Farkas
,
Norbert Kiss
,
Viktória Szabó
,
Miklós Resch
,
Rita Vámos
,
Ágnes Borbándy
,
Anikó Nagy
,
Astrid Apor
,
Tamás Arányi
,
Flóra Szeri
,
Norbert Wikonkál
,
Zoltán Nagy
,
Béla Merkely
, and
Márta Medvecz

Összefoglaló. A pseudoxanthoma elasticum (PXE, OMIM # 264800) egy autoszomális recesszív módon öröklődő multiszisztémás érintettséggel járó kórkép, melynek háttérében az ABCC6 gén mutációi állnak. A tünetek kialakulásának oka az ektópiás mineralizáció. Kalcium-só kristályok rakódnak le elsősorban a bőrben, a szem Bruch-membránjában és az erek endotheliumában, így a bőrelváltozások mellett a látás csökkenése és cardiovascularis eltérések is jelentkezhetnek. A klinikai tünetek változó súlyosságúak lehetnek, heterogén megjelenésűek. A betegek fenotípusának azonosítása, valamint gondozása multidiszciplináris feladat, bőrgyógyász, szemész, kardiológus és klinikai genetikus együttműködésén alapul. Célunk, hogy bemutassuk a betegségben előforduló tüneteket, melyek ismerete megkönnyíti a kórkép felismerését, illetve hogy felhívjuk a figyelmet a korai diagnózis fontosságára és ismertessük a korszerű diagnosztikai módszereket. A súlyos szisztémás tünetek kialakulása miatt rendkívüli jelentőséggel bír a társszakmák együttműködése, hogy a korai diagnózis által időben megfelelő gondozásban és terápiában részesülhessenek a betegek. Orv Hetil. 2022; 163(18): 702–711.

Summary. Pseudoxanthoma elasticum (PXE, OMIM # 264800) is an autosomal recessive, multisystemic disorder, associated with mutations of the ABCC6 gene. Ectopic mineralization is in the background of the clinical manifestations of the disease. Calcium-salt crystals are deposited primarily in the skin, in the Bruch membrane of the eyes, and in the vascular endothelium. Thus, in addition to the skin lesions, visual impairment and cardiovascular involvement also occur. Clinical symptoms show varying severity and display heterogeneous appearance. The identification of the phenotype and care of the patients require a multidisciplinary perspective based on the collaboration of a dermatologist, ophthalmologist, cardiologist, and clinical geneticist. The aim of our work is to describe the development of symptoms of the disease, in order to facilitate the diagnosis. In addition, we aim to draw attention to the importance of early diagnosis of pseudoxanthoma elasticum, and to present modern diagnostic methods. Considering the development of severe systemic complications, the early diagnosis with the collaboration between related specialists is crucial to provide optimal clinical care and management of the patients. Orv Hetil. 2022; 163(18): 702–711.

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