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be used for virtually any chemical reaction and are therefore cost efficient to operate. Nevertheless, since two decades or so, continuous-flow chemistry has become more widespread in academic synthetic chemistry groups that recognized the benefits of
1. Introduction The expansion of publications, presentations, and lectures on flow chemistry over the past decade has been remarkable. Once a field dominated by chemical engineers, flow techniques are now important
Further Flow Chemistry Publications: 2013 “ Heating under high-frequency inductive conditions: application to the continuous synthesis of the neurolepticum olanzapine (Zyprexa) ” J. Hartwig , S. Ceylan , L. Kupracz
Further Flow Chemistry Publications “ Transesterification of rapeseed oil under flow conditions catalyzed by basic solids:M-Al(La)-O (M=Sr, Ba),M-Mg-O (M=Y, La) ” Sherstyuk , O. V. , Ivanova , A. S. , Lebedev
far from straightforward. The microgravity (μg) environment affects convection and fluid dynamics, which results in an environment where conventional batch chemistry does not seem evident. In this perspective, we show why flow chemistry shall be the
As someone smart once said: “It is difficult to make predictions, especially about the future.” Very true indeed! Flow chemistry and continuous processing are not new research fields and have been around for many decades. Only recently
This paper describes the selective and reproducible debenzylation of benzyloxypyrazinones using flow chemistry to yield N-hydroxypyrazinones. Flow methodology enabled us to avoid overreduction of the compounds to pyrazin-2(1H)-ones.
continuous-flow chemistry, inline analytics, and automation technology has shown great potential to gather accurate reaction data [ 36 ]. Such integrated systems allow to reduce the total optimization time and the required amount of material. Recently, Jensen
Electrosynthesis is an old method currently moving again in the focus of organic synthesis. Some limitations of conventional electrosynthesis can be overcome by the use of electrochemical flow devices. This perspective indicates where the pitfalls, where the advantages and where the challenges are in implementing flow electrosynthesis as an alternative tool for the synthetic chemist.
In order for microflow electrolysis cells to make their full contribution to routine laboratory organic synthesis, they must be capable of carrying out reactions with good selectivity and high conversion at a high rate of conversion. In addition to appropriate choice of the electrolysis medium and control of the overall cell chemistry, both the design of the electrolysis cell (including materials of construction) and the correct selection of the cell current and flow rate of the solution are critical in determining performance. The conclusions are tested using the methoxylation of N-formylpyrrolidine as the test reaction in a microflow electrolysis cell with a single, long, patterned flow channel.