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Campylobacteriosis is mainly caused by infection with Campylobacter jejuni following consumption or handling of Campylobacter-contaminated poultry meat. The aim of this study was to investigate the effect of probiotic Enterococcus faecium AL41 on TGF-β4 and IL-17 expression and on immunocompetent cell distribution after C. jejuni infection in broiler chicken, as a second part of the previous study of Karaffová et al. (2017). Accordingly, day-old chicks were randomly divided into four experimental groups of 10 chicks each (n = 10): control (C), E. faecium AL41 (EFAL41), C. jejuni CCM6191 (CJ), and combined E. faecium AL41 + C. jejuni CCM6191 (EFAL41 + CJ). Samples from the caecum were collected on days 4 and 7 post Campylobacter infection (dpi), for the isolation of mRNA of TGF-β4, IL-17 and for immunohistochemistry. The relative mRNA expression of TGF-β4 was upregulated in the combined (EFAL41 + CJ) group compared to other groups during both samplings, but the expression of IL-17 was downregulated. Similarly, the highest density of CD3+ was detected in the combined group at 7 dpi, but the number of IgA+ cells was increased in both groups with EFAL41. It was concluded that the EFAL41 probiotic E. faecium strain can modulate the expression of selected cytokines (upregulation of TGF-β4 but downregulation of IL-17 relative expression), and activate IgA-producing cells in the caeca of chicks infected with C. jejuni CCM6191.

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Orvosi Hetilap
Authors: Olivér Rosero, Tibor Kovács, Péter Ónody, László Harsányi and Attila Szijártó

., Laissue, J. A.: Bacterial translocation in the normal human appendix parallels the development of the local immune system. Ann. N.Y. Acad. Sci., 2004, 1029 , 337–343. Takesue, Y., Ohge, H., Uemura, K., et al

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Lett. 2016; 590: 1602–1613. 56 Liu L, Wang Y, Fan H, et al. MicroRNA-181a regulates local immune balance by inhibiting proliferation and immunosuppressive properties of

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) 72. Sauer A , Rochet E , Lahmar I , Brunet J , Sabou M , et al.: The local immune response to intraocular Toxoplasma re-challenge: less pathology and better

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-3841.2011.02416.x 55. Han Z , Willer T , Pielsticker C , Gerzova L , Rychlik I , Rautenschlein S . Differences in host breed and diet influence colonization by Campylobacter jejuni and induction of local immune responses in chicken . Gut Pathog

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hypothesis. We assume a subsequent MRSA eradication by a strong local immune response and local inflammation attributed to the end of dexamethasone treatment at day 2 and its fast degradation [ 25 ]. This is supported by increased neutrophil counts in the

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