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Some studies suggested a positive effect against cardiometabolic diseases of supplementation of alpha-linolenic acid (ALA, C18:3 n-3) rich foods in pathological subjects, even if the total literature is controversial. In order to clarify ALA-rich chia seed action in hypertensive model with the overt pathology and without drug interference, in the present study the biochemical markers of cardiometabolic diseases (endothelin-1, ET-1; nitric oxide, NO; and bradykinin, BK) in Spontaneously Hypertensive Rats (SHRs) were analysed after 5% chia seed dietary supplementation for five weeks, and compared with the staple raw material wheat and corn. At the end of the experimental period, also plasma antioxidant capacity and inflammatory condition were evaluated. Our results showed that the chia seed group was more oxidized. On the other hand, ET-1 significantly decreased in chia seed group, and there was no difference between groups for NO, BK, and the inflammatory C-reactive protein (CRP). In conclusion, some positive effects of chia seed consumption on cardiometabolic markers in SHRs were observed, despite this the association of chia seeds with antioxidants is suggested to avoid plasma oxidation increase.

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Sohn Verlag , 2007 , p. 1032 . [13] R. Z. Kavtaradze , D. O. Onishchenko , A. A. Zelentsov , and S. S. Sergeev , “ The influence of rotational charge motion intensity on nitric oxide formation in gas-engine cylinder ”, Int. J. Heat Mass

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nitric oxide radicals to N 2 . Antioxidants act as a free radical quenching agent. Antioxidants blended with biodiesel produce fewer NO x emissions as a result of reducing the formation of free radicals. Fig. 7. Nitrogen Oxides (NO x ) vs. load 5

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.P. , Imran , Q.M. , Mun , B.G. , and Yun , B.W. ( 2019 ). Nitric oxide regulates plant responses to drought, salinity, and heavy metal stress . Environmental and Experimental Botany , 161 : 120 – 133 . 10.1016/j.envexpbot.2019.02.003 Nagy , J

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