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Physiology International
Authors:
N. Almási
,
Z. Murlasits
,
A. Al-awar
,
Á. Csonka
,
S. Dvorácskó
,
C. Tömböly
,
S. Török
,
D. Bester
,
A. Pósa
,
C. Varga
, and
K. Kupai

particularly in constipation and delayed transit time in the elderly. A plethora of evidence suggests that key signs of the aging process, such as loss of neurons in the gut, increase in the amount of aggregated proteins, elevation in oxidative stress and

Open access
Acta Veterinaria Hungarica
Authors:
Dániel J. Kócsó
,
Judit Szabó-Fodor
,
Miklós Mézes
,
Krisztián Balogh
,
Szilamér Ferenczi
,
András Szabó
,
Brigitta Bóta
, and
Melinda Kovács

The objective of this experiment was to determine whether fumonisin B1 (FB1) added to the diet of rats in a dose of 50 mg/kg changes the production of heat shock protein 70 (Hsp70) in the lungs and kidney of rats. We also studied the effect of this mycotoxin on the antioxidant system of the body. Mature (8 weeks old) male Wistar Crl:WI BR rats (n = 6/group) were fed the toxin-containing diet for 5 days. FB1 resulted in a 7% body weight reduction without significantly changing the feed intake. Western blot analysis of the lungs and kidney demonstrated a substantial (1.4-fold and 1.8-fold, respectively) increase in Hsp70 expression. Alterations could not be detected in the clinical chemical parameters (total protein, albumin, total cholesterol, glucose, creatinine and urea concentrations, and aspartate aminotransferase activity). There was no statistically significant change in malondialdehyde concentrations and the measured antioxidant parameters (the amount of reduced glutathione, GSH and glutathione peroxidase activity, GPx) in the blood plasma, lung and kidney tissue. Thus, it can be concluded that FB1 did not induce oxidative stress in the lungs and kidney, but increased Hsp70 production.

Open access
Orvosi Hetilap
Authors:
András Szarka
,
Gábor Bánhegyi
, and
Balázs Sümegi

–902. Fukui, H., Moraes, C. T.: The mitochondrial impairment, oxidative stress and neurodegeneration connection: reality or just an attractive hypothesis? Trends Neurosci., 2008, 31 (5), 251–256. Lieber, M. R

Open access

to apoptosis. Oxidative stress is a phenomenon which occurs in a cell when the concentration of ROS exceeds the antioxidant capacity. ROS can initiate the process of lipid peroxidation causing damage to phospholipids and lipoproteins of the cell

Open access
Acta Chromatographica
Authors:
S. Hiriyanna Hiriyanna
,
K. Basavaiah
,
P. S. Goud Goud
,
V. Dhayanithi
,
K. Raju
, and
H. Pati Pati

Summary

Studies of the degradation of olanzapine bulk drug under hydrolytic (acidic and alkaline), oxidising, and photolytic conditions are reported in this paper. Olanzapine is almost completely stable under photolytic and hydrolytic (acidic and alkaline) conditions. The major degradation products formed when olanzapine bulk drug was exposed to oxidative stress conditions were isolated by preparative reversed-phase high-performance liquid chromatography and characterized by FTIR, LC-MS-MS, and 1H, 13C, and DEPT NMR. On the basis of results from spectroscopy the degradation products were characterized as 10-hydroxy-2-methyl-5,10-dihydro-4H-benzo[b]thieno [2,3-e][1,4]diazepin-4-one, 2-methyl-5,10-dihydro-4H-benzo[b]thieno[2,3-e][1,4]diazepin-4-one, and 2-methyl-10-(2-methyl-10H-benzo[b]thieno[2,3-e][1,4] diazepin-4-yloxy)-5,10-dihydro-4H-benzo[b]thieno[2,3-e]diazepin-4-one. Identification, isolation, and characterization of these oxidative degradation products are discussed in detail.

Open access

against reactive oxygen species (ROS) ( Skrzydlewska et al., 2002 ; Prasanth et al., 2019 ). Therefore, in the current study, we investigated the effects of green tea on oxidative stress and hyperlipidaemia in the liver of the rats maintained with a high

Open access

oxidative stress and the high release of free radicals [ 3 ]. Oxidative stress is caused by the imbalance between the production of free radicals and reactive oxygen species on one hand, and antioxidant defense system on the other hand, and can have

Open access
Physiology International
Authors:
D. Gerszi
,
Á. Penyige
,
Z. Mezei
,
B. Sárai-Szabó
,
R. Benkő
,
B. Bányai
,
C. Demendi
,
E. Ujvári
,
S. Várbíró
, and
E.M. Horváth

biological pathways, where they act as mediators; however, their overproduction leads to oxidative/nitrative stress that takes part in the pathogenesis of numerous diseases [ 9, 10 ]. Oxidative stress increases during the course of physiological pregnancy

Open access

–19. 4 Cousins RJ, Liuzzi JP, Lichten LA. Mammalian zinc transport, trafficking, and signals. J Biol Chem 2006; 281: 24085–24089. 5 McLaren SH, Gao D, Chen L, et al. Oxidative stress and

Open access

. Cardiol., 2012, 60 (18), 1778–1786. 16 Schulz, E., Jansen, T., Wenzel, P., et al.: Nitric oxide, tetrahydrobiopterin, oxidative stress and endothelial dysfunction in

Open access