Authors:Natasza Krawczyk, Stanisław Karski, and Izabela Witońska
interaction, which may occur on the surface of bimetallic supportedcatalysts, was not taken into account. Moreover, there are a lot of different factors which may influence the activity and selectivity of bimetallic systems based on palladium. Considering the
Authors:Brecht Egle, Juan Muñoz, Nerea Alonso, Wim De Borggraeve, Antonio de la Hoz, Angel Díaz-Ortiz, and Jesús Alcázar
The first example of an alkyl–aryl Negishi coupling in a practical, sustainable, and high-yielding process using a silica-supported catalyst in flow is described. Excellent conversions and good functional group compatibility were obtained under very mild conditions. Functionalized alkyl groups were also introduced to provide access to synthetically useful molecules and to demonstrate the versatility of the method. The scalability was assessed, and a throughput of 7.5 mmol/h of processed substrate was achieved. All crude products were free from phosphine derivatives and ready for use in subsequent reaction steps.