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Journal of Radioanalytical and Nuclear Chemistry
Authors: A. Perera, C. Perez, M. Torres, A. Henandez, F. Heres, T. Moreira, A. Gutierrez, A. Gigato, I. Hernandez, L. Alberti, O. Marrero, L. Martinez, J. Sanfiz, E. Sanchez, J. Rodriguez, L. Marrero, and G. Parra

Abstract  

The aim of this work was to obtain a freeze-dried kit for direct99mTc-labeling of human polyclonal IgG. The labeling procedure was carried out by Schwarz's method. The best yields of99mTc-IgG were obtained by using sodium pyrophosphate decahydrate as a weak chelating agent. Performed tests showed the stability of the radiopharmaceutical up to 24 hours. Plasma clearance in rats was fitted to a biexponential curve withT 1/2α=(0.1 ±0.9) h andT 1/2β=(10±3) h. The organs with higher uptake of radiopharmaceutical were lung, kidneys and blood. In a rabbit model the abscess target/background ratio was 3–6 according to time of the scintigraphic images. Thirty patients with musculoskeletal infection were studied. Twenty-one lesions were detected and confirmed by culture/biopsy.

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