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Abstract  

To investigate the effects of lanthanum exposure on regional distribution of inorganic elements in rat brain. Wistar rats were exposed to lanthanum chloride through oral administration at 0, 0.1, 2, and 40 mg/kg concentration for 6 months. The elements such as Cl, K, Ca, Fe, Cu, and Zn were identified in the brain slices by synchrotron radiation X-ray fluorescence (SRXRF) analysis. Differences of brain elemental distributions were noticed. Cl, Ca, and Zn were primarily concentrated in hippocampus of the controls. With the increase of the lanthanum dosage, the Ca and Zn levels significantly decreased, while the Cu levels significantly elevated in cortex, hippocampus and thalamus. Our results suggest that subchronic lanthanum exposure in rats appears to change elemental distributions in brain.

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Shuganjieyu (SGJY) capsule is a classical formula widely used in Chinese clinical application. In this paper, an ultra-performance liquid chromatography coupled with electrospray ionization and ion trap mass spectrometry has been established to separate and identify the chemical constituents of SGJY and the multiple constituents of SGJY in rats. The chromatographic separation was performed on a C18 RRHD column (150 × 2.1 mm, 1.8 μm), while 0.1% formic acid–water and 0.1% formic acid–acetonitrile was used as mobile phase. Mass spectral data were acquired in both positive and negative modes. On the basis of the characteristic retention time (R t) and mass spectral data with those of reference standards and relevant references, 73 constituents from the SGJY and 15 ingredients including 10 original constituents and 5 metabolites from the rat plasma after oral administration of SGJY were identified or tentatively characterized. This study provided helpful chemical information for further pharmacology and active mechanism research on SGJY.

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Journal of Thermal Analysis and Calorimetry
Authors: Li-Fang Song, Cheng-Li Jiao, Chun-Hong Jiang, Jian Zhang, Li-Xian Sun, Fen Xu, Qing-Zhu Jiao, Yong-Heng Xing, F. L. Huang, Yong Du, Zhong Cao, Fen Li, and Jijun Zhao

Abstract

One-three-dimensional metal-organic frameworks Mg1.5(C12H6O4)1.5(C3H7NO)2 (MgNDC) has been synthesized solvothermally and characterized by single crystal XRD, powder XRD, FT-IR spectra. The low-temperature molar heat capacities of MgNDC were measured by temperature modulated differential scanning calorimetry (TMDSC) over the temperature range from 205 to 470 K for the first time. No phase transition or thermal anomaly was observed in the experimental temperature range. The thermodynamic parameters of MgNDC such as entropy and enthalpy relative to reference temperature of 298.15 K were derived based on the above molar heat capacities data. Moreover, the thermal stability and decomposition of MgNDC was further investigated through thermogravimetry (TG)–mass spectrometer (MS). Three stages of mass loss were observed in the TG curve. TG–MS curve indicated that the oxidative degradation products of MgNDC are mainly H2O, CO2, NO, and NO2.

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