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Acta Chromatographica
Authors: S. M. Nurulain, H. Kalász, P. Szegi, K. Kuca, A. Adem, M. Y. B. Hasan, F. Hashemi, and K. Tekes

Summary

HPLC monitoring of pharmacokinetics was done in two body compartments of rats following intramuscular treatments with three different doses of K027, a bispyridinium mono-aldoxime type of antidotes to organoposphate intoxicated subjects. Reversed-phase HPLC separation with electrochemical detections was done to monitor the onset, the maximum level, and offset in K027 concentration. Serum level of K027 showed a fast onset, independently from the doses of K027. Drug level in brain was showing an essentially delayed kinetics.

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