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  • Author or Editor: J. Volford x
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Abstract  

Mercaptoacetyltriglycine and its related compounds were synthesized and labeled with99mTc-radionuclide in order to study the effect of substituents and labeling conditions upon the formation of radioactive by-products. Direct labeling and ligand exchange reactions were followed by radio-TLC separation. The direct labeling in alkaline media at elevated temperature provides high radiochemical yields and gives opportunity for a new kit formulation because the neutralization to physiological pH does not cause any change in the chemical identity of the complexes. Compounds with the strongly polar sulfonyl groups show significantly lower protein binding compared with mercaptoacetyltriglycine and may be considered as potential renal agents.

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Abstract  

Radiometric method was developed for the analysis of endogenous formaldehyde in human blood and urine using dimedone-14C reagent. The method based on that dimedone /5,5-dimethyl-cyclohexane-1, 3-dione/ can very easily condense with formaldehyde and other aldehydes. With the help of this radiometric method a sensitive technique and a more accurate evaluation have been made possible. Applying this method it could be established that the formaldehyde level in the blood varies between 0.4–0.6 g ml–1 and in urine 2.5–4.0 g ml–1. The error of determination and the chemical bonds of formaldehyde in the biological fluids are discussed.

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