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Acta Veterinaria Hungarica
Authors: Sung Jae Kim, Van Giap Nguyen, Cheong Ung Kim, Bong Kyun Park, Thi-My Le Huynh, Sook Shin, Woo Kyung Jung, Yong Ho Park, and Hee Chun Chung

Abstract

Porcine epidemic diarrhoea virus (PEDV) is one of the major pathogens causing acute enteritis, which is characterised by vomiting and watery diarrhoea and commonly leads to high rates of mortality and morbidity in suckling piglets. Chitosan has been regarded as a promising natural disinfectant. In this study, the disinfectant effect and mammalian-cell toxicity of chitosan were evaluated against PEDV using Vero cells. A 0.01% solution of chitosan was determined to be an effective disinfectant. In addition, no evidence of toxicity was observed during the cell toxicity test; on the contrary, chitosan promoted cell proliferation. In conclusion, chitosan is a promising candidate for an effective and safe disinfectant against PEDV as well as other coronaviruses.

Open access