Authors:G. Patyi, A. Bódis, I. Antal, B. Vajna, Zs. Nagy, and Gy. Marosi
Solvent and melt techniques were used to obtain molecular dispersion of the poorly soluble spironolactone (SPIR) model drug
enhancing its dissolution rate. DSC study of the interaction between SPIR and hydroxypropyl-β-cyclodextrin confirmed the need
for molecular dispersion if their complexation is required. Solvent-free twin-screw extrusion was suitable for forming inclusion
complex significantly below the melting temperature of the SPIR. According to DSC, Raman and XRPD results fine dispersion
of both components was achieved in a hydrophilic polymer. The molecules of the active ingredient are separated from each other
in the polymer and the lack of the lattice energy causes faster dissolution.