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In order to investigate the effects of exposure to possible environmental pollutants such as Cd, Pb and Hg on haematological and serum biochemistry values, New Zealand White female rabbits were treated orally with distilled water solutions of CdSO4·H2O, Pb(NO3)2 and HgCl2 (n = 4/treatment) in concentrations of 2.3, 4.1, and 30 mg/kg dry matter, respectively, for 28 days. The initial concentrations of Cd, Pb, and Hg in serum were significantly increased by the treatment. Exposure to Pb significantly decreased the red blood cell (RBC) count, haemoglobin (Hgb) concentration and the haematocrit (Hct) value. The Zn-protoporphyrin concentration did not change as a result of Pb exposure. Pb and Hg loading significantly increased the aspartate aminotransferase (AST) activity. Alanine aminotransferase (ALT) activity was also increased by both Hg and Cd exposure. Comparing the treated and the control rabbits, all the trace elements studied significantly reduced the activity of enzymes in the pancreatic tissues. The haematological results indicate that hyperchromic macrocytic anaemia developed in rabbits treated with Pb. The increased activities of both AST and ALT indicate pathophysiological changes of the liver parenchyma, which was verified by focal fatty infiltration seen histopathologically. Cd exposure could exert a toxic effect on the kidneys, although the slight tubulonephrosis developed would not possibly affect the renal function. The reduced activities of amylase, trypsin, protease and lipase induced by Cd, Pb and Hg suggest toxicity to the pancreas.

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Acta Veterinaria Hungarica
Authors: Zoltán Demeter, Elena Palade, Éva Balogh, Csaba Jakab, Róbert Farkas, Balázs Tánczos, and Sándor Hornok

Here we report a case of canine babesiosis with unusual morphology of the causative agent. A male, seven-week-old Labrador retriever puppy, exhibiting severe anaemia and haemoglobinuria, was presented at the Clinic of Internal Medicine in February 2011. The puppy was euthanised. The most relevant pathological changes were icterus, severe splenomegaly, generalised lymphadenopathy and haemoglobin nephrosis. Samples were collected from various organs for histology within one hour post mortem. Impression smears were also prepared from the spleen after overnight storage at 4 °C. Tissue sections and smears showed the presence of multiple, coccoid intraerythrocytic bodies that measured 1–2 μm and resembled small babesiae. No large piroplasms were seen. DNA was extracted from the spleen, and a conventional PCR was performed for the amplification of a 450-bp region of the 18S rRNA gene of piroplasms. The causative agent was identified as Babesia canis canis, with 99% sequence identity to other European isolates. Sequence identity to B. gibsoni was only 91%. This is the first account to verify that the morphology of the large canine piroplasm, B. canis, can be uniformly small babesia-like post mortem or following the storage of tissue samples.

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Acta Veterinaria Hungarica
Authors: Nikitas Prassinos, Katerina Adamama-Moraitou, Haralabos Ververidis, Tilemachos Anagnostou, and Stefanos Kladakis

A 1.5-year-old German Shepherd mixed breed dog was admitted with mild haemorrhage from the vulva and a perineal mass of 24-hour duration, which had been first observed immediately after parturition. Parturition had occurred at low ambient temperature, and only one puppy survived out of the seven oversized fetuses. The dog was in poor body condition, dehydrated, hypothermic, depressed, non-ambulatory and in a state of shock. Intestinal loops, the urinary bladder and the uterine horns and body were protruding from the vulva. A true vaginal prolapse was also observed. The abdominal viscera were flushed with warm sterile saline solution, protected and maintained wet. The laboratory findings included moderate anaemia, leukocytosis, hypoalbuminaemia, azotaemia and elevated liver enzyme activities. Stabilisation of the dog’s general condition was attempted before surgery. Antimicrobial and analgesic drugs were also administered. After exploratory laparotomy the protruding organs, which were in good condition, were reduced. A recent rupture in the vaginal wall, approximately 6 cm long, was observed. Ovariohysterectomy and partial vaginectomy were performed. The preoperative course of therapy was continued, but the bitch died 12 hours later. The probable cause of vaginal rupture and evisceration in this bitch was tenesmus and/or trauma due to the oversized fetuses.

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Orvosi Hetilap
Authors: Géza Bozóky, Éva Ruby, Ilona Góhér, Andrea Mohos, Csilla Bálint, and István Bozóky

A szolid malignus kórképekben laboratóriumi módszerekkel igazolható fokozott trombózishajlam a daganatsejtek haemostasisrendszerre gyakorolt aktiváló hatása következtében alakul ki. Az aktiváló hatás a daganatsejtek és a koagulációs rendszer különböző alkotóelemei (véralvadási faktorok, thrombocyták, endothel, fibrinolitikus rendszer) közötti interakció révén alakul ki, s ez vezet a protrombotikus állapottól a haemostasisrendszer klinikailag megnyilvánuló zavaraihoz. Célkitűzés: Retrospektív analízis során a szerzők arra kerestek választ, hogy nagy esetszámú szolid malignus daganatos betegben milyen jellegű és gyakoriságú haemostaticus rendellenességek fordulnak elő. Módszer: Az 1996 és 2004 közötti időszakban 1381 betegben hisztológiai és/vagy citológiai vizsgálat révén kórisméztek szolid malignus megbetegedést. A betegek többsége primer bronchopulmonalis kiindulású karcinómában szenvedett ( n = 1140). A többi esetben emlő-, colorectalis, vese-, húgyhólyag-, pajzsmirigy- és pancreaslokalizációjú volt a malignus folyamat, mesotheliomát hat betegben kórisméztek. A stádiummegállapító vizsgálatok alapján a betegek nagyobb hányada előrehaladott klinikai stádiumú volt. A daganatos betegekben azt vizsgálták, hogy milyen jellegű és gyakoriságú haemostaticus rendellenesség fordul elő, különös tekintettel a vénás thromboemboliák előfordulására. Külön is figyelmet fordítottak a meglevő nem malignus társbetegség szerepére a haemostaticus rendellenességek kialakulása szempontjából. Eredmények: Az 1381 rosszindulatú daganatos betegben 397 esetben (28,7%) észleltek klinikailag megnyilvánuló haemostaticus rendellenességet. Leggyakoribbnak a mélyvénás trombózis és akut pulmonalis embólia bizonyult ( n = 305, 22%). Egyéb jellegű haemostasiszavar (migráló felületes thrombophlebitis, szeptikus trombózis, akut diffúz intravascularis coagulatio, microangiopathiás haemoliticus anaemia) 71 betegben fordult elő, amely 6,7%-nak felel meg. A haemostaticus eltéréssel járó malignus kóresetek 40%-ában nem malignus társbetegséget észleltek, különböző cardialis megbetegedések, valamint a krónikus obstruktív tüdőbetegség dominanciájával. A fokozott trombóziskészséget kiváltó szisztémás okok mellett közel 10%-os gyakoriságban a jelentős nagyságú lokoregionális tumorvolumen is hozzájárult a vénás keringési zavar kialakulásához. Következtetések: Szolid malignus betegekben a daganatsejtek és a koagulációs szisztéma egyes alkotóelemei közötti interakció fokozott trombózishajlam kialakulásához vezet, melynek következtében különböző klinikai megjelenésű haemostasis-rendellenességek jelentkezhetnek. Ezen haemostasiszavarok közül a klinikai gyakorlatban leggyakrabban a vénás thromboemboliák fordulnak elő. Idiopátiás vénás trombózisok eseteiben célzott vizsgálatok elvégzése indokolt az aszimptomatikus (okkult) malignus betegség igazolása, illetőleg kizárása céljából.

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Acta Biologica Hungarica
Authors: D. Boonkusol, A. Dinnyés, Mayurachat Sa-ardrit, Saovaros Svasti, Tassanee Faisaikarm, J. Vadolas, Suthat Fucharoen, and Yindee Kitiyanant

A major clinical feature of patients with thalassemia is growth retardation due to anemia, therefore, the hematological parameters, weanling weight and post-weanling weight of pups obtained from vitrifiedwarmed embryo transfers were studied for the first time in this report. Two-cell embryos of four transgenic (TG) thalassemic mouse lines (BKO, 654, E2, and E4) were produced by breeding four lines of TG thalassemic males to wild-type (WT) females (C57BL/6J) and were cryopreserved by vitrification in straws using 35% ethylene glycol. After transfer of vitrified-warmed embryos, hematological parameters, spleen index, weanling and post-weanling weight were determined in TG and WT viable pups. In the BKO and 654 mice significantly abnormal hematological parameters and spleen index were observed compared to WT, E2 and E4 mice. The weanling and post-weanling weights of BKO and 654 pups were significantly less than that of the age-matched WT pups. However, no significant differences in weanling and post-weanling weight were found between WT and E2-TG or E4-TG pups. In conclusion, the four transgenic mice lines produced from cryopreserved embryo transfer retain the phenotype of the natural breeding mice indicating that these banked embryos are appropriate for thalassemia model productions.

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Balázs T. (szerk.): A Budapesti Fővárosi István Kórház történetének 100 éve: 1885–1985. Budapest. 1985, 30. Bence Gy.: Az anaemia gyógykezelésének alapelve. Gyógyászat, 1936, 76 , 387

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Orvosi Hetilap
Authors: Zsolt Reiger, Gergely Varga, Beáta Tóth, László Maródi, and Melinda Erdős

775 Knight, S. W., Heiss, N. S., Vulliamy, T . J. és mtsai: Unexplained aplastic anaemia, immunodeficiency, and cerebellar hypoplasia (Hoyeraal–Hreidarsson syndrome) due to

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Orvosi Hetilap
Authors: Enikő Sáfrány, Veronika Csöngei, Luca Járomi, Anita Maász, Lili Magyari, Csilla Sipeky, and Béla Melegh

Pearson, H. A., Lobel, J. S., Kocoshis, S. A. és mtsai: New syndrome of refractory sideroblastic anemia with vacuolization of marrow precursors and exocrine pancreatic dysfunction. Journal of Pediatrics, 1979, 95 , 976

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Magyar Sebészet
Authors: László Agócs, Bernadett Lévay, Ákos Kocsis, Györgyi Szabó, Eldin Mohamed Gamal, Lívia Rojkó, József Sándor, and György Wéber

Absztrakt

Bevezetés: Az invazív aspergillosis életet veszélyeztető kórkép immunsupprimált betegeknél, mivel roncstüdő kialakulásához vezethet. Az Aspergillus empyema kezelése összetett. Eset: 18 éves férfi beteget kezeltünk, akinek anamnaesisében pancytopenia hátterében aplasticus anaemia, ciklosporin-A anti-thymocyta globulin (CA ATH) kezelés szerepel. Eredménytelen idegen donoros őssejtbeültetést követően gombás pleuropneumonia alakult ki nála, így empyema kialakulása miatt „open window thoracostomiát” (OWT), fenestratiót készítettünk. Ismételt mellkasi CT készült septicus állapot miatt, a korábbi műtét során készített stomából multidrog-rezisztens Pseudomonas tenyészett ki. Intézetünkbe történő áthelyezését követően az üreg debridementjének elvégezése után a musculus latissimus dorsi (MLD) és a musculus serratus anterior (MSA) izmok felhasználásával thoracomyoplasticát végeztünk. A műtétet követően parenchymaveszteség nélkül hazabocsátottuk a beteget. Következtetés: Az aspergillus okozta empyema kezelése nyitott thoracostomiával és halasztott izomlebeny-plasztikával szelektált esetekben sikerhez vezet, a tüdő funkciójának megtartásával. Ezen eset is példa arra, hogy társszakmák (jelen esetben mellkassebész és plasztikai sebész) együttműködése vezethet a sikeres gyógyuláshoz.

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Haematological and biochemical analyses of blood were performed in carp (Cyprinus carpio L.) kept in small ponds. Caught and anaesthetised carp were clinically examined and blood samples were taken at regular intervals during the three years. In the first year of examinations, the haemoglobin and haematocrit values of carp fry significantly increased (P<0.01) from June to September. The intensive growth of carp in the summer period in the second year was accompanied by adequate erythropoiesis. During hibernation haematocrit and haemoglobin significantly decreased (P<0.05) and mean corpuscular haemoglobin concentration (MCHC) increased (P<0.01) in both scaly and mirror carp. MCHC increased also with the age and increasing body weight of the fish. Mirror carp had lower haematocrit and haemoglobin values than scaly carp (P<0.01). Comparative haematological analyses between carp of normal and poor body condition showed that moderate anaemia appeared in those with poor body condition. The results indicate that there is marked seasonal and age-dependent variation in the values of haematocrit and haemoglobin. Pond water quality investigations indicated good environmental conditions. A 50% increase (P<0.05) of glucose concentration was found from June to September in the blood plasma of carp in the third year, accompanied by an even more increased (80%; P<0.01) concentration of total lipids. At the same time, considerable changes of cholesterol and total protein concentrations were not observed. The results suggest that the investigated haematological and biochemical variables could be successfully utilised in monitoring the metabolic balance and health status of fish in intensive culture.

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