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examined at several levels. These designs are designated as response surface methodology [ 5, 6 ]. The most commonly used response surface designs include: full factorial design on three levels, central composite design, Box–Behnken design and Doehlert

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concentration. Response surface methodology (RSM) is a methodology based on the suitability of experimental data to a polynomial equation, consisting of mathematical and statistical techniques. RSM looks for statistical explanation for the behavior of a

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number of factors. The most significant factors indicated by the Pareto chart were optimized using a Box–Behnken design (response surface methodology) based on 3-level factorial design. The number of experiments ( n ) was 20, which is calculated

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degradation of indole in UV/TiO 2 : optimization and modelling using the response surface methodology (RSM) . Environ Chem Lett . 7 : 45 – 49 10.1007/s10311-008-0137-2 . 7. Sakkas , VA , Dimou

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Response surface methodology for eicosanoic acid triboproperties in castor oil . Tribol Int. 42 : 50 – 58 10.1016/j.triboint.2008.05.018 . 6. Causseau , T , Graca , B , Campos , A

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.07.004 . 2. Vázquez , G , Freire , MS , Santos , J , Antorrena , G , González-Álvarez , J . Optimisation of polyphenols extraction from chestnut shell by response surface methodology . Waste Biomass Valoris . 2010 ; 1

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.08.006 Sablania , V. and Bosco , S.J.D. ( 2018 ). Optimization of spray drying parameters for Murraya koenigii (Linn) leaves extract using response surface methodology . Powder Technology , 335 : 35 – 41 . 10.1016/j.powtec.2018.05.009 Singh , S. and

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Acta Alimentaria
Authors: S. Hu, H. Shu, J.L. Yuan, J.Y. Gao, P.Y. Mu, C.Z. Ren, W. Sang, L.C. Guo, and H.B. Chen

.04.053 Setm , D . & Rajamanickam , G . ( 2012 ): Development of extruded snacks using soy, sorghum, millet and rice blend–a response surface methodology approach . Int. J. Food Sci. Tech. , 47, 1526 – 1531 . Smarma , P ., Gujral , H.S . & Sinum , B

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surface methodology and their structural characteristics . Innov. Food Sci. Emerg ., 12 , 305 – 309 . 10.1016/j.ifset.2011.03.003 Chunu , Y.C ., Chen , C.H ., Tsaı , Y.T ., Lın , C.C ., Chou , J.C ., & Hsu , C.P . ( 2017 ): Litchi seed

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from the fruit pulp of Euterpe edulis using the response surface methodology . Food Res. Int. , 44 , 708 - 715 . 10.1016/j.foodres.2010.12.025 Danişman , G. , Arslan , E. & Toklucu , A.K. ( 2015 ): Kinetic analysis of anthocyanin

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