This paper presents the result of thermodynamic studies on Ge1−xSnxSe2.5 (0 ≤ x ≤ 0.5) glasses using differential scanning calorimetry. The obtained experimental results on phase transformations have been
employed to obtain thermodynamic parameters like entropy difference between metastable states in the glassy region, difference
of Gibbs free energy, specific heat, entropy between the glassy and the crystalline phase and the enthalpy released during
phase transformation (glassy to crystalline). The results yield that, Ge0.7Sn0.3Se2.5 sample is least stable among all the samples. The stability increases on addition of Sn beyond 0.3 at. mass% upto 0.5 at.
Authors:Yuanyou Yang, Rushan Lin, Ning Liu, Jiali Liao, Min Wei, and Jiannan Jin
With 2,3,5,6-tetrafluorophenyl 3-(nodo-carboranyl) propionate (TCP) as a new potential bi-functional linker, bovine serum albumin (BSA) was conjugated with 211At, and the conjugated model protein (211At-TCP-BSA) was preliminarily evaluated in vitro and in vivo by comparison with 211At-SAB-BSA and 211At-SAPC-BSA, which conjugated with 211At via aryl derivatives ATE (N-succinimidyl-3-(tri-n-butylstannyl) benzoate) or SPC (N-succinimidyl 5-(tributylstannyl)-3-pyridinecarboxylate). The radiolabeled intermediate 211At-TCP was coupled to BSA in yields ranging from 35 to 45% with radiochemical purity of more than 98%. The conjugated 211At-TCP-BSA exhibited considerable stability in vitro in 0.1 mol/L PBS (pH 7.6) at room temperature (RT), similar to 211At-SAPC-BSA and 211At-SAB-BSA. Biodistribution of the 211At conjugated protein was investigated in NIH strain mice by I.V injection. The results showed that 211At-TCP-BSA was constantly stable in vivo as well as in vitro, but more stable than 211At-SAPC-BSA and 211At-SAB-BSA. These results implied that radioastatinated carboranes based on B–At bonds are higher stability than radioastatinated
aryl derivatives based on C–At to in vivo deastatination. In other word, TCP should be a promising bi-functional linker for
211At conjugation of proteins or antibodies.
Authors:Grażyna Janowska, Agnieszka Kucharska-Jastrząbek, and Przemysław Rybiński
. As a result, the oscillation amplitude of polymeric chain segments is reduced and consequently the temperatures of degradation and destruction of the filled polymer are increased [ 4 ].
The increase in the thermal stability of nanocomposites