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pathogen . J Clin Outcomes Manag 2010 ; 17 : 363 – 369 . [2] Jahangiri S , Malekzadegan Y , Motamedifar M , Hadi N . Virulence genes profile and biofilm formation ability of Acinetobacter baumannii strains isolated from inpatients of a
plays an important role in surface-associated motility and in virulence [ 9 ]. Our aim was to characterize the mechanisms of quinolone resistance and to investigate the presence of the novel abaQ gene among A. baumannii clinical isolates causing VAP
The association between putative virulence genes in Campylobacter jejuni clinical isolates, in vitro invasive capability and severity of infection is yet to be clearly described. We have characterized three virulence genes and correlated their presence with the severity of infection and in vitro invasiveness. We studied eight C. jejuni strains isolated from patients whose clinical data were scored to determine severity of infection. Cytolethal distending toxin (cdtB) , invasion associated marker (iam) and Campylobacter invasion antigen (ciaB) genes were detected by PCR and INT407 cells used for invasion assays. Two strains positive for all three genes were the most invasive and isolated from patients with the most severe infection. Four strains positive for two genes and two strains negative for all the three genes were identified. The two cdtB + ve / ciaB + ve strains were more invasive than the cdtB + ve / iam + ve strains. One of the cdtB − ve / ciaB − ve strains showed invasion levels similar to cdtB + ve / ciaB + ve strains, but the second strain had a non-invasive phenotype. The findings indicate a correlation between in vitro invasive capability, and the presence of all three genes. The pattern of association between invasiveness and molecular characterization suggests that the ciaB gene confers a more invasive capability.
virulence of the virus, on crowded places, on the hygiene and behaviour of the person, and on co-infection with other pathogens [ 18 ]. Diagnosis Diagnosis is based on clinical findings and demonstration of the virus RNA. Detecting antibodies generated
Discussion Emerging evidence indicates that Pg has a more complex relationship with the host. It is not only considered as the most virulent periopathogen but rather a “key-stone pathogen” possessing an array of virulence factors and the potential
] Xie X , Dai X , Ni L , Chen B , Luo Z , Yao Y , et al. Molecular epidemiology and virulence characteristics of Staphylococcus aureus nasal colonization in medical laboratory staff: comparison between
pathogenicity of P. gingivalis is reflected in a lot of different important virulence factors involved in tissue colonization and destruction, and interference with host defense systems. Peri-implant inflammation and lesions are of multifactorial nature, but
global epidemiology of carbapenemase-producing Enterobacteriaceae . Virulence 2017 ; 8 : 460 - 469 . https://doi.org/10.1080/21505594.2016.1222343 . 10.1080/21505594.2016.1222343 13. Spyropoulou A , Papadimitriou-Olivgeris M , Bartzavali C
– 127 . Ito , N. , Takayama , M. , Yamada , K. , Sugiyama , M. and Minamoto , N. ( 2001 ): Rescue of rabies virus from cloned cDNA and identification of the pathogenicity-related gene: glycoprotein gene is associated with virulence for adult
virulence and did not cause significant clinical signs. In such cases, disease control measures and immunisation have resulted in an environment that does not favour virus persistence within the herd. In addition to the continuous laboratory testing of
