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Introduction Globally, hospital-acquired infections (HAIs) pose a significant burden to healthcare workers and patients with respect to health, time, resources, and cost. The prevalence of HAIs widely varies from 5.7% to 19
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-pathogenic, but in 1978, C. difficile was identified as the leading cause of antibiotic-associated diarrhea and a major cause of pseudomembranous colitis [ 2 ]. The epidemiology of C. difficile infection (CDI) has recently undergone a dramatic change worldwide
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