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Orvosi Hetilap
Authors: Mihály Makara, Gábor Horváth, Judit Gervain, Alajos Pár, Ferenc Szalay, László Telegdy, István Tornai, Eszter Újhelyi, and Béla Hunyady

2007 45 507 539 Raimondi, S., Maisonneuve, P., Bruno, S., et al.: Is response to antiviral treatment

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Abstract

Introduction: The 2009 pandemic 2009 H1N1 (pH1N1) influenza A virus shows a markedly different disease pattern than seasonal strains, causing critical illness in relatively young, female, pregnant individuals as well as in comorbid patients. Materials and methods: The Department of Anesthesiology and Intensive Therapy of Semmelweis University served as a regional influenza center for the adult critically ill during the winter of pH1N1 outbreak. We analyzed data collected from 26 suspected pH1N1 critically ill patients treated in our unit during this period. Results: Sixteen cases were confirmed as pH1N1 infection with RT-PCR, while the other 10 patients with influenza like illness showed tendency to a different age and comorbidity, as well as outcome characteristics, suggesting a different pathogenesis. Confirmed pH1N1 patients showed a mean age of 50.5 years (median: 44; range: 20–85), with female predominancy (69%). Comorbidity was present in 69% of cases (chronic heart conditions, chronic pulmonary disease, previous history of malignancy present in 31; 25 and 19%, respectively). Twenty-five percent of the patients were pregnant women. Nineteen percent of the cases received previous pH1N1 vaccination. But two patients were later readmitted for worsening chronic conditions that led to death, which resulted in a total mortality rate of 31%. Mean APACHE II and SOFA scores on admittance were 12.2 and 5.3, respectively. Average length of treatment was 11.5 days (median: 6.5; range 2–50 days). All patients received ventilatory assistance, 69% of patients received invasive, while 31% of patients received non-invasive ventilatory assistance. The average number of days of invasive ventilation was 10.5 days (median: 5.5; range: 2–45). Forty-five percent of ventilated patients required rescue ARDS therapy. Complications included hemodynamic instability (56%); acute renal failure (13%) and pneumothorax (13%). Superinfection with other microbes were observed in 56% of the patients. Conclusions: In our study, pH1N1 infected critically ill patients had a wide age range, but were more commonly female, pregnant, or had a previously described underlying disease. Mortality, length of treatment, need for invasive mechanical ventilation, length of mechanical ventilation, major complication rates were similar to those previously described. A previously not reported relatively high occurrence of pneumothorax was noted, which is possibly a long-term complication of severe viral pneumonitis.

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Orvosi Hetilap
Authors: Tamás Schneider, Zsuzsanna Molnár, Beáta Deák, Erika Várady, Erika Tóth, Judit Csomor, András Matolcsy, József Lővey, Zsolt Lengyel, Klára Petri, István Gaudi, and András Rosta

235 242 Czuczman, M. S., Grillo-Lopez, A. J., White, C. A. és mtsai: Treatment of patients with low-grade B-cell lymphoma with the combination of chimeric anti

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(8), 1120–1125. Early Treatment for Retinopathy of Prematurity Cooperative Group: Revised indications for the treatment of retinopathy of prematurity: results of the early treatment for retinopathy of prematurity randomized

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Orvosi Hetilap
Authors: Tamás Gáti, Attila Pajor, Pál Géher, and György Nagy

mtsai: The effects of rituximab treatment during pregnancy on a neonate. Haematologica, 2006, 91 , 1426–1427. Salwender H. The effects of rituximab treatment during pregnancy on

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effectiveness of HCV treatment in national VA practice. J. Hepatol., 2012, 56 , 320–325. Richardson P. Gaps in the achievement of effectiveness of HCV treatment in national VA practice

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Orvosi Hetilap
Authors: Béla Telek, László Rejtő, Péter Batár, Gyula Reményi, Róbert Szász, Attila Kiss, and Miklós Udvardy

: Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute – Working Group 1996 guidelines. Blood, 2008, 111 , 5446

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Orvosi Hetilap
Authors: Róbert Jaskó, Endre Horváth, Anna Szilágyi, and Áron Altorjay

Dreno, B.: Standard and new treatments in cutaneous B-cell lymphomas. J. Cutan. Pathol., 2006, 33 , 47–51. Dreno B. Standard and new treatments in cutaneous B-cell lymphomas

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Acta Veterinaria Hungarica
Authors: Anna Linda Nógrádi, Iain Cope, Márton Balogh, and János Gál

References Askew , A. R. ( 1978 ): Treatment of acute and chronic gastric volvulus . Ann. R. Coll. Surg. Engl. 60 , 326 – 328

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Orvosi Hetilap
Authors: Gábor Horváth, Zsuzsanna Gerlei, Judit Gervain, Gabriella Lengyel, Mihály Makara, Alajos Pár, László Rókusz, Ferenc Szalay, László †Telegdy, István Tornai, Klára Werling, and Béla Hunyady

), 1379–1385. www.kozlonyok.hu/kozlonyok/Kozlonyok/6/PDF/2011/7.pdf [Hungarian] Horváth, G., Hunyady, B., Gervain, J., et al.: Diagnosis and treatment of chronic hepatitis B and D. Hungarian national consensus

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