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, C. (2007) Pharmacokinetics and absolute bioavailability of selegiline following treatment of healthy subjects with the selegiline transdermal system (6 mg/24 h): a comparison with oral selegiline capsules. J. Clin. Pharmacol. 47 , 1256

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Acta Chromatographica
Authors: Yonghui Shen, Deru Meng, Feifei Chen, Hui Jiang, Liming Hu, Yunfang Zhou, and Miaomiao Zhang

Use Committee of Wenzhou Medical University (NO. wydw2017-0010) and were following the Guide for the Care and Use of Laboratory Animals. Absolute bioavailability (Fabs) was the non-intravenous dose-corrected AUC divided by AUC intravenous, calculated

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dose. Absolute bioavailability was found to be 50% on day 1 and 68% on day 5. Similarly, after 40 mg oral administration, peak plasma concentration was increased by 95% (2.38 µmol/L versus 4.64 µmol/L) and the AUC by 159% (4.32 µmol × h/L versus 11

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Acta Chromatographica
Authors: Qinghua Weng, Lianguo Chen, Luxin Ye, Xiaojie Lu, Zheng Yu, Congcong Wen, Yichuan Chen, and Gang Huang

. Bioavailability was calculated as Absolute bioavailability = 100% × AUCpo · Div/(AUCiv · Dpo), where AUCiv and AUCpo are the AUC of the drug from 0 to ∞ after intravenous and oral administration. Div and Dpo are the single dosage of licochalcone A for intravenous

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Acta Chromatographica
Authors: Shanjiang Chen, Miaoling Huang, Zheng Yu, Jiamin He, Binge Huang, Xianqin Wang, Jianshe Ma, and Congcong Wen

equation is as follows: absolute bioavailability (%) = (AUC PO × D IV /AUC IV × D PO ) × 100. Results and Discussion Method Optimization Various methodologies are used to evaluate ESI mass

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Acta Chromatographica
Authors: Haiya Wu, Mengrou Lu, Jiamin He, Miaoling Huang, Aote Zheng, Meiling Zhang, Congcong Wen, and Jufen Ye

Pharmaceutical University) in the non-compartment mode for fitting the pharmacokinetic parameters. Absolute bioavailability was defined as the percentage AUC ratio of oral administration to intravenous injection. Results and Discussion

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Acta Chromatographica
Authors: Aixia Han, Guanyang Lin, Jinzhang Cai, Qing Wu, Peiwu Geng, Jianshe Ma, Xianqin Wang, and Chongliang Lin

concentration ( C max ), and half-life ( t 1/2 ) were analyzed using a non-compartmental model with DAS 2.0 software (China Pharmaceutical University). The equation of bioavailability was as follows: absolute bioavailability = AUC of oral administration/AUC of

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substrate ISR (a calcium channel blocker antihypertensive BCS II drug having oral absolute bioavailability of 15%–34% due to presystemic metabolism) by inhibiting the enzyme using bioenhancer like Ru, thereby improving the oral bioavailability. The ONbp

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