Authors:P. Bowen, M. Daglish, G. Frenzer, J. -F. Ricard, and Y. Wyser
Aluminate sodalite ceramics, (Sr8Al12O24)(CrO4)2) — SACR, have been prepared from solution spray-dried precursors. The spray drying of a mixed aqueous nitrate solution gave an anhydrous powder which was thermally decomposed in air at 1350 °C to give a crystalline SACR powder with a median volume diameter of 4–6 μm. The SACR powder was dry pressed and sintered to >90% density. The yellow SACR powder showed two phase transitions between 10 and 45 °C with a 25 ° intermediate phase region indicative of a low defect concentration in the crystalline structure. A colour change observed in the sintered ceramic (changing to a mixed green/yellow) and a narrowing of the phase transition region (15–40 °C) are discussed. Dielectric measurements were consistent with the presence of two extrinsic ferroelectric transitions at 17 and 35 °C.
Authors:J. Ginés, M. Arias, C. Novák, P. Sánchez-Soto, A. Ruiz-Conde, and E. Morillo
The formation of crystalline inclusion complex of triamterene with β-cyclodextrin (β-CD) was studied, evaluating the thermal
behaviour and dispersion state of this drug in different types of binary systems. Spray-drying and co-grinding (oscillating
mill) mixtures of triameterene with β-CD were prepared in 1∶1 molar ratio. The changes of crystalline properties of original
(untreated) triamterene, β-CD, and composites obtained by co-grinding and spray-drying were investigated in comparison with
those produced in simple physical mixtures. The thermal behaviour of the different samples was investigated using DTA. X-ray
diffraction was applied as a complementary technique. The results have been explained by formation of amorphous drug particles
on spray-drying samples and co-grinding or alternatively by means of a solid dispersion formation or a combination of these
two. A contamination effect by grinding media was also observed as increasing grinding time.
The interaction among moisture content, solvent loss and glass transition temperature is relevant for processing of spray-dried
pharmaceuticals, since the glass transition temperature determines the application range of a compound. Conventional Differential
Scanning Calorimetry (DSC) does usually not allow to separate glass transitions from common kinetic effects like evaporation
or crystallization. Based on classical DSC methods, the IsoStepTM method allows the independent determination of heat capacities and kinetic effects, and thus, the separation of kinetic effects
from effects arising from heat capacity changes. This technique is used to separate glass transition and evaporation processes,
and to find the relation between moisture content and glass transition temperature for a pharmaceutical sample based on a
modified Gordon–Taylor equation.
, A. & Noreña , C.P.Z. ( 2015 ): Encapsulation of red cabbage ( Brassica oleracea L. var. capitata L. f. rubra) anthocyanins by spraydrying using different encapsulating agents . Braz. Arch. Biol. Techn. , 58 , 944 – 952
Authors:Jutta Breitenbach, Christopher Beermann, and Günter J. Esper
Jantzen , M. ; Göpel , A. ; Beermann , C. ( 2013 ) “ Direct SprayDrying and Microencapsulation of Probiotic Lactobacillus Reuteri from Slurry Fermentation with Whey ”, in Journal of Applied Microbiology 115 ( 2013 ), pp. 1029 – 1036
Authors:J.A. Pino, E. Sauri-Duch, O. Sosa-Moguel, C.A. Can-Cauich, V.M. Moo-Huchin, and L. Cuevas-Glory
libraries. The constituents of the aroma distillate were quantified after the areas of each detected compound were normalised and expressed as a percentage area. Process optimisation for the spraydrying and volatiles retention was done by using the total
Authors:Jadwiga Skubiszewska-Zięba and V. Sydorchuk
The influence of the conditions of aerosil dispersion spray drying process in the medium of overheated water steam on the
formation of microspheric granules and their porous structure was studied. Water and ammonium solutions as aerosil particles
dispersing agents and water steam and air as heat carriers were used. It was stated that the effects of spray drying depend
on the kind of dispersing medium and on the conditions of atmosphere and temperature at which drying and forming of aerosilogel
granules takes place.
Authors:Luciana Fernandes, W. Oliveira, J. Sztatisz, and Cs. Novák
Microencapsulation of Lippia sidoides essential oil was carried out by spray drying. Blends of maltodextrin and gum arabic were used as carrier. Spray dried microparticles
were characterized using conventional (thermogravimetry, evolved gas analysis) and combined (thermogravimetry-mass spectrometry
analysis) thermal analysis techniques in order to evaluate the abilities of carriers with different compositions in retaining
and in releasing the core vs. dynamic heating. Thermal analysis was useful to evaluate the physico-chemical interactions between
the core and carriers and to determine the protective effect of the carriers on the evaporation of essential oil.
Authors:P. Sipos, A. Szabó, I. Erős, and Piroska Szabó-Révész
A study was made of the possibilities of gradually decreasing the concentration of the toxic organic solvent in the process
of microsphere preparation. Ammonio methacrylate copolymer-based microspheres were prepared by spray drying or conventional
solvent evaporation techniques, and compared. The formulations were designed by varying the preparation methods and the concentrations
of four polar cosolvents as independent variables.
DSC was used to study the relationship between the changes in the independent variables and three of the main thermal events
of the microspheres. Raman spectroscopy was used to investigate and confirm the possible interactions between drug and copolymer.
Appropriate choice of the independent variables led to the molecularly dispersed drug in the polymer matrix. It was demonstrated
that only the nature of the preparation method caused significant variations in the structure and thermal behaviour of the