Authors:H. Poorbaygi, Sh. Sheibani, S. Aghamiri, and M. Shamami
Intra-hepatic administration of radioactive glass microspheres is a treatment for patients with primary liver cancer and hepatic
metastases. The purpose of this study was radionuclide purity assessment of new glass particles containing two radionuclide,
90Y as a therapeutic source and also 177Lu as a source of diagnostic gamma. For the mixed source, activity measurement using a dose calibrator cannot be used and
we need new calibration methods. YAS (Yb) and YAS compositions were sol–gel derived glass particles and production of 90Y (177Lu) and 90Y particles was performed using the Tehran Research Reactor. The radionuclide purity was carried out using γ-spectrometry
with HPGe detector. A non-destructive spectroscopic assay was employed due to a newly updated low uncertainty positron branching
ratio of 90Y that emit 511 keV annihilation radiations. In another method, a new calibration of 90Y using a non-destructive spectroscopic assay of 88Y were investigated. Potential radionuclide impurity include: 88Y, 152Eu, 60Co with activity 100, 50 and 5 Bq per 1 mg of that are not harmful for patients due to delivering radioactive particles about
20–50 mg in 90Y(177Lu) glass microspheres. Among of radionuclide impurity, 152Er with a half life of 13.54 years and 88Y with a half life of 106.65 days was important in the residual delivery device. For calibration of 90Y with monitoring of 511 keV, errors were12.2–21%. In calibration of 90Y using gamma spectroscopic assay of 88Y, there was an error less than 14%. Spectroscopic assay of 88Y can be performed easily and has more repeat for our purpose.
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Authors:A. Sheikhi-Garjan, A. Hosseini-Gharalari, M. Mahjob, M. Rashid, Q. Sabahi, M. Safari, F. Jalilyan, and R. Arbabtafti
Organization, Nashr-e Amozesh keshvarzi , Karaj, Iran , 150 p.
Gerami , K. ( 2005 ): Study on three kinds of sprayers in control of wheat weeds in Ardabil region . MS thesis, Research–Science Department of Islamic Azad University , Tehran, Iran