Thyroid hormones (THs) are crucial for growth and development and particularly brain development. The present study was carried out to investigate the brain derived neurotrophic factor (BDNF) and Oxidative stress index (OSI) in the brain of pups born to dams with methimazole (MMI) induced hypothyroidism. Also, to elucidate the effectiveness of selenium (Se) in ameliorating the brain damaging effects induced by maternal hypothyroidism. Our results reveled that plasma free T3 (FT3), free T4 (FT4), growth hormone (GH) were significantly decreased while plasma thyroid stimulating hormone (TSH) was significantly increased in the pups. BDNF level significantly decreased while OSI significantly increased in both the hippocampus and cerebellum in pups born to hypothyroid dams. Se supplementation significantly alleviated the levels of these parameters. The biochemical modifications were confirmed histologically with the abnormal development of the hippocampus and cerebellum and partial reversal of these effects with Se supplementation. We concluded that reduced hippocampal and cerebellar BDNF levels and increment of oxidative stress during early development may contribute to the adverse neurodevelopmental effects of hypothyroidism during pregnancy. Also, Se is an important neuroprotective element that may be used as a dietary supplement against brain damage induced by hypothyroidism.
Authors:M. Szeitz-Szabó, L. Bíró, Gy. Bíró, and J. Sali
In 2009 Hungarian Food Safety Office (HFSO) performed a countrywide representative dietary survey to obtain food consumption data for quantitative food safety risk assessment utilizable in the field of public health nutrition as well. The consumption of foodstuffs, daily energy- and nutrient intakes, nutritional habits and dietary supplement usage of Hungarian population was assessed. The complex system has included three-day dietary record and a food consumption frequency questionnaire. Some anthropometric parameters were also self-recorded. According to the body mass index, a considerable proportion of both the 31–60 years old males (69%) and females (46%) were overweight or obese. The energy intake of the Hungarian adult population is slightly exceeds the recommendation. The intake of proteins is satisfactory in general. The average intake of total fats is very high (36.1–38.9 energy percent), and the fatty acid composition — mostly the ratio of n-6/n-3 fatty acids — is unfavourable, but the fatty acid pattern regarding saturated- (SFA), mono- (MUFA) and polyunsaturated (PUFA) fatty acid ratio shows favourable tendency. The proportion of complex carbohydrates within the intake of energy providing macronutrients is far lower than the optimal level, but it is a positive finding that added sugar intake is below the outmost recommendation. The average daily cholesterol intake is high (males: 469 mg, females: 335 mg), whilst the dietary fibre intake is lower than the recommended. The article provides data on alcohol, caffeine and fibre consumption, too.
Authors:P. Bhatia, C. Bansal, R. Prakash, and T.P. Nagaraja
The present study was carried out to examine the antioxidant activity in oyster mushroom cultivated on selenium (Se) rich substrate. Pleurotus fossulatus was cultivated on Se-rich wheat straw collected from the seleniferous belt of Punjab (India) and its potential to accumulate Se from substrate was examined. Using different assay systems the modulations in the anti-oxidant profile of Se enriched mushroom was studied in comparison to the mushrooms cultivated on normal straw. The oyster mushrooms were observed to potentially mobilize Se from Se-rich substrates to fruiting bodies, resulting in significantly high uptake (37.2±0.6 μg g−1) as compared to control (3.57±0.53 mg g−1). The antioxidant activity, as determined by various assays, such as reducing power, 2,2-diphenyl-1-picrylhydrazyl free radical scavenging, and metal chelating activity, was higher in the experimental mushrooms when compared to control. The results obtained demonstrate that Se-fortified mushrooms through cultivation on straw containing organic forms of Se can be considered as natural and effective dietary supplements of organic Se for humans. The present study proposes the use of Se-rich agricultural residues as substrates for mushroom cultivation for human and livestock supplementation.
Authors:L. Biró, M. Szeitz-Szabó, Gy. Biró, and J. Sali
The fourth countrywide nutrition survey was initiated and co-ordinated by the Hungarian Food Safety Office jointly to the yearly Household Budget Survey of Hungarian Central Statistical Office in 2009. The dietary assessment was performed by trained interviewers and skilled dieticians using a complex questionnaire system, containing three-day diary, short food frequency questionnaire and questions on taking of dietary supplements and on prevalence of food allergy. The data records were processed and the questionnaires were validated, the results obtained on the micronutrient intakes of the adult population are shown in this article. From fat soluble vitamins, the average daily intakes of vitamins A and D were lower than the national recommendations in case of both genders, meaning low intake for around 60% (in case of retinol) and 80–90% (in case of calciferols) of adults. The intakes of some water soluble vitamins belonging to B group, vitamin C and folates were low as well. Regarding the macroelements, the most important health problem on population level is the extremely high sodium load of the inhabitants, combined with unfavourable sodium/potassium ratio. The average daily calcium intake of every age and gender group was far below the recommended value. The average daily intake of iron was low for the 50% of adult females. The article also provides data on frequency of food supplement taking habits of inhabitants and of self-reported food allergy.
Authors:N. Costa, P. Sakon, H. Paula, M. Pinto, M. Sant‘Anna, T. Araújo, and V. Minim
This study aimed to evaluate the composition, the protein quality, and the acceptability of a powder dietary supplement formulated for elderly people. The centesimal composition was analysed according to A.O.A.C. methods and the protein quality was assessed in weaning rats, by comparing Protein Efficiency Ratio (PER), Net Protein Ratio (NPR), and True Digestibility (TD) of the supplement with a casein-control based on AIN-93G diet. For the acceptance test samples of four flavours of the supplement dissolved in whole milk were offered to each judge, in monadic form. To assess the overall acceptability a scale of seven points was used. The sensory panel was composed of 121 Brazilian panellists, with mean age of 68.28±5.78 years. The supplement is promising in reaching the nutritional demands of the elderly, providing high content of protein and fibre and low content of fat. The values found for PER and NPR were shown to be superior to the control group of casein (P<0.05) and the digestibility was higher than 90%, showing that the supplement presented characteristics of a high nutritional value protein source. The supplements with banana, vanilla, and strawberry flavour were the most accepted and did not differ significantly for the overall acceptability.
Authors:Iveta Placha, Lubica Chrastinova, Andrea Laukova, Klaudia Cobanova, Jana Takacova, Viola Strompfova, Maria Chrenkova, Zuzana Formelova, and Stefan Faix
The effects of 0.5 g thyme oil per kg dry matter (DM) of diet on duodenal tissue integrity, antioxidant status, phagocytic activity and selected microbiota in the caecum and faeces of rabbits were studied. Twenty-four rabbits were divided into two groups and were fed a commercial granulated diet for growing rabbits (CD) with access to water ad libitum. The first group was fed the CD, while to the CD of the second group thyme oil was added. Intestinal integrity was tested by measuring the transepithelial electrical resistance (TEER). Thyme oil significantly increased the value of total antioxidant status (TAS) in the blood plasma and glutathione peroxidase (GPx) activity in the liver, and it decreased malondialdehyde (MDA) concentration in the duodenal tissue. Thyme oil resulted in strengthened intestinal integrity, as the essential oil supplementation significantly increased TEER values in the experiment. The faecal microbiota of rabbits was almost completely balanced in both groups, and only a slight decrease was found in the microbial population at day 42 of the trial. In both groups, the bacterial counts were generally lower in the caecum than in the faecal samples. In conclusion, dietary supplementation with 0.5 g/kg DM thyme oil may improve intestinal integrity, and it may have an antioxidant effect. A tendency was also found for thyme oil to stimulate the abundance of some microbes beneficial in the rabbit gut.
Authors:László Pál, Margit Kulcsár, Judit Poór, László Wágner, Szabolcs Nagy, Károly Dublecz, and Ferenc Husvéth
A study was conducted to examine the effects of different oils on the plasma corticosterone concentrations of broiler chickens fed ad libitum or deprived of feed for 24 hours. A total of 36 Ross broilers were randomly assigned to one of three dietary treatments at 10 days of age and fed a grower diet supplemented with 60 g/kg soybean oil (rich in linoleic acid, C18:2n–6), linseed oil (rich in a-linolenic acid, C18:3n–3) or fish oil (rich in C14:0, C16:0, C16:1n–7, C20:1n–9; eicosapentaenoic acid and docosahexaenoic acid, EPA, C20:5n–3 and DHA, C22:6n–3), respectively, for 18 days. Dietary supplementation of fish oil resulted in lower (P < 0.05) baseline plasma corticosterone levels of chickens fed ad libitum for 18 days compared to soybean and linseed oil supplementations. Feed deprivation for 24 h induced a significant (P < 0.05) increase in corticosterone concentration in every treatment group compared to the ad libitum-fed birds. The hormone levels of feed-deprived birds did not differ significantly among groups fed diets supplemented with different oils.
Authors:L. Costantini, R. Molinari, and N. Merendino
Some studies suggested a positive effect against cardiometabolic diseases of supplementation of alpha-linolenic acid (ALA, C18:3 n-3) rich foods in pathological subjects, even if the total literature is controversial. In order to clarify ALA-rich chia seed action in hypertensive model with the overt pathology and without drug interference, in the present study the biochemical markers of cardiometabolic diseases (endothelin-1, ET-1; nitric oxide, NO; and bradykinin, BK) in Spontaneously Hypertensive Rats (SHRs) were analysed after 5% chia seed dietary supplementation for five weeks, and compared with the staple raw material wheat and corn. At the end of the experimental period, also plasma antioxidant capacity and inflammatory condition were evaluated. Our results showed that the chia seed group was more oxidized. On the other hand, ET-1 significantly decreased in chia seed group, and there was no difference between groups for NO, BK, and the inflammatory C-reactive protein (CRP). In conclusion, some positive effects of chia seed consumption on cardiometabolic markers in SHRs were observed, despite this the association of chia seeds with antioxidants is suggested to avoid plasma oxidation increase.
Authors:Zsófia Küronya, Tamás Martin, Edina Kiss, Mihály Szőnyi, and Krisztina Bíró
A kannabisz a legnépszerűbb lágy drogok közé tartozik, a kávé, a dohány és az
alkohol után világszerte a negyedik legtöbbet fogyasztott pszichoaktív szer. A
két legismertebb növényi kannabinoid, a szigorúan ellenőrzött pszichotrop
delta-9-tetrahidrokannabinol és a pszichoaktív hatással nem rendelkező, 2004 óta
Magyarországon is elérhető, csupán bejelentési kötelezettséggel járó,
étrend-kiegészítőnek minősülő kannabidiol. Az orvosi célú kannabisz
használatával kapcsolatban, főleg onkológiai indikációban, számos tévhit kering.
Közleményünkben összefoglaljuk a kannabisz történetét, hatásmechanizmusát, az
onkológiai alkalmazásra jelenleg rendelkezésre álló evidenciákat, a jogi
szabályozást, és külön felhívjuk a figyelmet a kannabidiol alkalmazásakor
felmerülő potenciális veszélyekre. Orv Hetil. 2020; 161(25): 1035–1041.
Utilization of algae includes both macroalgae for human consumption dating back to thousands of years, as well as the application of microalgae in health promoting dietary supplements. The autotrophic growth of microalgae is slow, but can be accelerated by optimizing their cultivation conditions. Efficiency optimizations for time and economy should be performed in many parallel experiments. A new high-throughput microalgae cultivation method is presented here, applying 24-low-well microplate with varying illumination, in which the cell growth is followed via evaluation of scanned images. A strain of the genus Nannochloropsis and two Chlorella vulgaris species have been chosen as well described and frequently applied model organisms in order to test the recently developed cultivation system. In these scaled down experiments, the custom design lighting panel was tested by studying the effect of the colour of illumination on cell growth kinetics. RGB LEDs (i.e. light emitting diodes, red: 622 nm, green: 528 nm, and blue: 467 nm) were used individually or together providing red, green, blue, and white colours. While the effect of light’s colour on algae growth was evaluated, also the new system was proven to be suitable for comparing maximal growth rates for different microalgae strains. While the tested two Chlorella isolates reached 1.2–1.4 g l–1 concentrations, the Nannochloropsis strain reached 1.4 g l–1 final cell dry weight, and specific growth rates were observed between 0.58–0.62 day–1.