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We have previously described unexpected two-dimensionality in the thin-layer chromatographic separation of pairs of enantiomers of chiral 2-arylpropionic acids (2-APA) by one-dimensional development on a chiral stationary phase prepared by impregnating silica gel layers with l -arginine. The two-dimensionality of this separation was because in planar chromatography all analytes undergo two-dimensional effective diffusion and thus — theoretically at least — can migrate in two mutually perpendicular directions, i.e. in the direction of the mobile phase flow and in a direction perpendicular to this. Demonstration (and quantification) of this striking behavior was possible by use of densitometric detection. Migration of analytes in a direction perpendicular to that of the mobile-phase certainly is not commonplace in thin-layer chromatography and, as far as we are aware, the example described in our previous paper was the first of its kind reported. It was apparently induced by the chirality of the analytes and the stationary phase.In the work discussed in this paper we demonstrated another example of deviation from the vertical of the migration tracks of the same analytes, optically pure S -(+)-ibuprofen and S -(+)-naproxen, when chromatographed on unmodified commercial precoated silica gel plates. Keeping in mind that (i) such deviations can occur only with a chiral analyte developed in an asymmetric chromatographic system, and that (ii) silicon dioxide (chemically identical with chromatographic silica gel) can crystallize as quartz (i.e. as rock crystal) in two asymmetric — left-handed and right-handed — forms, we assumed the working hypothesis that chromatographic silica gel layers can also seem to have an asymmetric microcrystalline structure responsible for deviation from the vertical of the migration tracks of chiral analytes. To verify our hypothesis we acquired circular dichroism (CD) spectra and UV absorption spectra of samples of the silica gel used for coating commercial TLC plates. The results obtained from these measurements provide convincing evidence of the correctness of our hypothesis and it seems most likely that the commercial silica gel layers are characterized by the crystalline asymmetry of the silicon dioxide particles.

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safety of celecoxib, naproxen, or ibuprofen for arthritis. N Engl J Med. 2016; 375: 2519–2529. 18 Schjerning Olsen AM, Fosbøl EL, Lindhardsen J, et al. Duration of

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Orvosi Hetilap
Authors: László Hodinka, Géza Bálint, Erika Budai, Pál Géher, Renáta Papp, Péter Somogyi, Sándor Szántó, and Edit Vereckei

: 801–805. 48 Moorman CT, Kukreti U, Fenton DC. The early effect of ibuprofen on the mechanical properties of healing medial collateral ligament. Am J Sports

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Orvosi Hetilap
Authors: Gábor Lakatos, László Herszényi, and Zsolt Tulassay

: Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial [TARGET), reduction in ulcer complications: randomised controlled trial. Lancet, 2004, 364 , 665

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, Kalantari H, Gesztelyi R, Lekli I, Czompa A, Tosaki A: Summative interaction between astaxanthin, Ginkgo biloba extract (EGb761) and vitamin C in suppression of respiratory inflammation: a comparison with ibuprofen. Phytother. Res. 25(1), 128–136 (2011

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Orvosi Hetilap
Authors: Ákos Fábián, István László, Marianna Juhász, Mariann Berhés, Tamás Végh, György Koszta, Csilla Molnár, and Béla Fülesdi

] 25 Day M. Covid-19: ibuprofen should not be used for managing symptoms, say doctors and scientists. BMJ 2020; 368: m1086. Doi: https://doi.org/10.1136/bmj.m1086 (Published 17 March

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Acta Biologica Hungarica
Authors: Mónika Homa, Kinga Hegedűs, Ádám Fülöp, Vanessza Wolfárt, Shine Kadaikunnan, Jamal M. Khaled, Naiyf S. Alharbi, Csaba Vágvölgyi, and László Galgóczy

ibuprofen and azoles on Candida resulting from blockade of efflux pumps as determined by FUN-1 staining and flow cytometry . J. Antimicrob. Chemother. 56 , 678 – 685 . 24

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Controlled release injectable liposomal gel of ibuprofen for epidural analgesia Int J Pharm 199 85 93 . 24. G

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., Akeda, T. Contact dermatitis from ibuprofen piconol. Cont. Derm., 1988, 18 , 188–198. Akeda T. Contact dermatitis from ibuprofen piconol Cont. Derm

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. Sebők , D. , Csapó , E. , Preocanin , T. , Bohus , G. , Kallay , N. , Dékány , I. 2013 . Adsorption of ibuprofen and dopamine on functionalized gold using surface plasmon resonance spectroscopy at solid-liquid interface . Croatia

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