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A tüdő- és emlődaganatok áttétet képezhetnek az agyhártyán. A leptomeningealis carcinomatosis a daganatsejtes gócok elhelyezkedésétől függően szinte bármilyen központi idegrendszeri tünet formájában megmutatkozhat. A diagnózis a cerebrospinalis folyadék citológiai vizsgálata során észlelhető daganatsejtek kimutatásán alapul. A meningitis carcinomatosa prognózisa kezelés nélkül mindössze néhány hétre vagy hónapra korlátozódik. Amennyiben a meningitis carcinomatosa emlődaganat szövődményeként alakul ki, intrathecalis methotrexat-kemoterápiával a túlélés és az életminőség az esetek mintegy felében jelentősen javítható. Orv. Hetil., 2012, 153, 1385–1388.
. Lung Cancer, 2009, 10 , 360–363. Sze D. Y. Computed tomography-guided percutaneous needle biopsy of pulmonary nodules: impact of nodule size on diagnostic accuracy
Abstract
Lung cancer and smoking are associated. Epidemiological studies show that not only lung cancer but other chest diseases have causative relationship with smoking. Cigarette tobacco and smoke contains many carcinogens. Inorganic and metallic constituents of cigarette tobacco and smoke have not been studied as extensively as the organic compounds. Since some of the metals are highly toxic and also carcinogenic, authors have attempted to measure the levels of some of the trace elements of Indian tobacco by instrumental neutron activation analysis, and compared the results with the tobacco of America, Germany, Iran and New Zealand.
–9 16 Ming-Hui Hung, Kuang-Cheng Chan, Ying-Ju Liu, Hsao-Hsun Hsu, Ke-Cheng Chen, Ya-Jung Cheng, Jin-Shing Chen: Nonintubated thoracoscopic lobectomy for lung cancer using epidural
Brahmer, J., Reckamp, K. L., Baas, P., et al.: Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N. Engl. J. Med., 2015, 373 (2), 123–135. 33
Abstract
The Environmental Protection Agency has estimated that 20,000 lung cancer deaths per year may be related to radon exposure. This paper briefly describes the approach used to derive the Agency's central estimate of risk to the population. The weight-of-evidence for classifying radon as a known human carcinogen and the uncertainties associated with estimating risks from radon exposure provide an important context for these estimates and are briefly discussed.
Annema, J. T., van Meerbeeck, J. P., Rintoul, R. C., et al.: Mediastinoscopy vs. endosonography for mediastinal nodal staging of lung cancer: a randomized trial. JAMA, 2010, 304 , 2245–2252. Rintoul R. C
Abstract
The Californium User Facility for Neutron Science has been established at Oak Ridge National Laboratory (ORNL). The Californium Use Facility (CUF) is a part of the larger Californium Facility, which fabricates and stores compact252Cf neutron sources for worldwide distribution. The CUF can provide a cost-effective option for research with252Cf sources. Three projects at the CUF that demonstrate the versatility of252Cf for biological and biomedical neutron-based research are described: future establishment of a252Cf-based neutron activation analysis system, ongoing work to produce miniature high-intensity, remotely afterloaded252Cf sources for tumors therapy, and a recent experiment that irradiated living human lung cancer cells impregnated with experimental boron compounds to test their effectiveness for boron neutron capture therapy.
Abstract
Radiolabeled somatostatin analogues, including octreotate have been used for targeted radiotherapy of neuroendocrine tumors such as lymphoma, breast cancer, small-cell lung cancer and melanoma. In this paper, studies on the optimization of the production of 177Lu, 166Ho and 153Sm radionuclides in Pakistan Atomic Research Reactor (PARR-I) and the investigations on the labeling of DOTA-Tyr-3 Octreotate with 131I, 177Lu, 166Ho and 153Sm have been reported. The labeled DOTA-Tyr3-Octreotate complexes were found to be stable in acetate/ascorbate buffer and saline at room temperature (18–22°C). The biodistribution studies of 177Lu-DOTA-Tyr-3 Octreotate in rat model indicated that the critical organ for this complex was the pancreas and the excretion route was through kidney.
–130. Onimaru, R., Shirato, H., Shimizu, S., et al.: Tolerance of organs at risk in small-volume, hypofractionated, image-guided radiotherapy for primary and metastatic lung cancers. Int. J. Radiat. Oncol. Biol. Phys., 2003, 56 (1), 126
