reported that psoralidin also has multiple pharmacological activities such as anti-tumor [ 2 – 7 ], anti-osteoporosis [ 8 – 12 ] and enhancement of immunity [ 13 – 15 ]. Studies have shown that psoralidin can release a large amount of Ca 2+ in the
In-vivo neutron activation analysis (IVNAA) has been used in this laboratory, approximately for the past twenty years, to determine the bone status of humans. For this purpose, the total body calcium (TBCa) is assayed and that is indicative of the bone mineral concentration of the individual. We have effectively used this method to diagnose, understand and monitor the treatment of osteoporosis among elderly women, particularly in post-menopausal women. This paper summarizes the technique and our experience in dealing with osteoporosis.
Authors:B. Schäffer, B. Keller, Z. Szakály, and D. Lőrinczy
All over the world, but, first of all, in so called ‘civilized’ countries the osteoporosis, the ‘latent epidemic’ is still spreading. The situation is especially critical in countries, where the milk product
Authors:Zhang Yuanxun, Li Deyi, Zhuang Guisun, Zhang Guilin, Wang Zhixing, and Xia Jun
This paper deals with the osteoporosis model of New Zealand rabbits in order to study the function of inorganic elements for
women patients with osteoporosis. The thirty cases of iliac crest are collected and determined using neutron activation analysis
(NAA). The results show that the fluorine concentrations in the experimental group are higher than those in control group
and the magnesium concentrations are significantly lower (P<0.001), but the concentrations of K, Na, Ca, Ba, Mn, Sr show no
remarkable difference. Combined with the serum biochemical markers of bone formation and resorption, the physiological functions
of some metal elements in bone are also discussed.
Authors:V. Spate, J. Morris, C. Baskett, M. Mason, C. Reams, D. Hunter, and W. Willett
The role of fluorine in human health has become somewhat controversial. It is widely accepted as protective against dental caries, may be protective against osteoporosis, and has been very conservatively implicated with osteosarcoma in male rats. In this study, we repot on the development of a neutron activation analysis method and its application to the analysis of human nails. We have found that toenails collected in population-based epidemiology studies apparently reflect fluoride intake.
Authors:N. Aras, G. Yilmaz, S. Alkan, and F. Korkusuz
There is an evidence that some of the essential trace elements are crucial determinants of bone health. Excess or deficiency
of these elements has a role in the development of bone diseases, therefore research on trace elements in bone is very important.
Iliac crest bone biopsies were optioned from twelve persons undergoing orthopedic surgery due to any reason than osteoporosis.
Cortical and trabecular parts were separated, and blood and fats were removed. Up to 30 minor and trace elements were determined
in these samples by instrumental neutron activation analysis and other techniques and their relations were discussed.
An accurate knowledge of the ratio Ca/P in bone biopsies is very useful in the diagnosis of osteoporosis. Similarly, measurements
on muscle biopsies are important in understanding the disturbance of intracellular fluid and electrolyte (Na, Cl, K and P)
balance in patients with metabolic myopathies (muscle diseases) and acid-base disturbances including renal failure. The ratio
Ca/P in normal subjects was found to be 2.30. Similarly, the ratio K/P was found to be very nearly constant in normal subjects.