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-osteoporosis effect. High-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) has been successfully applied to the determination of psoralidin in biological matrix. Yang et al. develop a liquid chromatographic–tandem mass spectrometry (LC
mechanistic study and target identification. Rapid, simple, and reliable high-performance liquid chromatography with ultraviolet detection (HPLC/UV) and liquid chromatography with electrospray ionization tandem mass spectrometry (LC–ESI-MS/MS) methods
and calycosin. In this study, we used ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) combining multiple reaction monitoring (MRM) technique for the simultaneous determination of five isoflavones in rat plasma
and rapid ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method for the simultaneous determination of atractylenolide I, II, and III in rat plasma [ 1 ]. Plasma samples were processed by liquid–liquid extraction with
years, liquid chromatography–mass spectrometry (LC–MS) or liquid chromatography–tandem mass spectrometry (LC–MS/MS) has become a mature technique with many applications to various biological matrixes in cortisol and cortisone analyzing fields [ 11 – 18
use a rapid method to determine the true molecular structure of such compounds. Mass spectrometry (MS) has been widely used for the structural determination of flavonoids [ 21 , 22 ]. Liquid chromatography combined with tandem mass spectrometry (LC
chromatography–tandem mass spectrometry (LC–MS/MS). This method was successfully used in the pharmacokinetic studies of supinoxin in rats and may be useful for the development of clinical data. Experimental Reagents and
pH using the mixture of acetonitrile and 0.1% formic acid (45:55, v / v ) as a mobile phase. The analytical run time was 3.5 min. In this paper, an ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method with an
reported. Compared with capillary-zone electrophoresis, HPLC, and LC–MS, an ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method was more sensitive, high throughput, and time saving [ 16 – 20 ]. In this study
. Chemical structures of (A) irsogladine (left) and lamotrigine internal standard (right) and representative fragmentation patterns of (B) the electrospray ionization (ESI)–tandem mass spectrometry (MS/MS) spectra of the protonated molecular ion of
