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. Chemical structures of (A) irsogladine (left) and lamotrigine internal standard (right) and representative fragmentation patterns of (B) the electrospray ionization (ESI)–tandem mass spectrometry (MS/MS) spectra of the protonated molecular ion of

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Acta Chromatographica
Authors: Shuanghu Wang, Zixia Lin, Ke Su, Jing Zhang, Lijing Zhang, Zhimou Gao, Zhiyi Wang, Jianshe Ma, and Xianqin Wang

, Germany). Ultra-pure water was prepared by Millipore Milli-Q purification system (Bedford, MA, USA). Instrumentation and Conditions Ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) with

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of non-metabolized GLM [ 6–9 ]. Also, liquid chromatography-tandem mass spectrometry (LC-MS) has been developed for its determination [ 10–13 ]. Generally, two extraction procedures were used for the recovery of GLM from plasma, including liquid

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Acta Chromatographica
Authors: Jong-Woo Jeong, Yun-Hwan Seol, Hun-Chan Hyun, Hye-Rim Kim, Jong-Hwa Lee, Young-Dae Gong, Nam Sook Kang, and Tae-Sung Koo

chromatography–tandem mass spectrometry (LC–MS/MS). This method was successfully used in the pharmacokinetic studies of supinoxin in rats and may be useful for the development of clinical data. Experimental Reagents and

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Acta Chromatographica
Authors: Qinghua Weng, Lianguo Chen, Luxin Ye, Xiaojie Lu, Zheng Yu, Congcong Wen, Yichuan Chen, and Gang Huang

reported. Compared with capillary-zone electrophoresis, HPLC, and LC–MS, an ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method was more sensitive, high throughput, and time saving [ 16 – 20 ]. In this study

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mass spectrometry (UHPLC-MS/MS) is an excellent method for the selective and sensitive determination of small molecular weight compounds in biological samples [ 6, 7 ]. Fenofibrate is a prodrug that is hydrolyzed immediately after absorption by tissue

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using ultra-high performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS). In the present study, we established a simple, sensitive, and rapid liquid chromatography (LC)–MS/MS method and validated for determination of PH in dog plasma

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chromatography-diode array detector-hyphenated with tandem mass spectrometry (HPLC–DAD–ESI-MS/MS) was performed to investigate the dynamic changes of trifoliate oranges during the different fermentation statues. Multivariate statistical analyses, including

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established a simple, sensitive, and rapid liquid chromatography–tandem mass spectrometry (LC–MS/MS) method and validated for determination of PHL in rat biological samples using resveratrol as internal standard; meanwhile, it was successfully applied to

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Acta Chromatographica
Authors: Su Lian-Lin, Cheng Xue, Ding Xi-Yan, Mao Chun-Qin, Lu Tu-Lin, Hao Min, Li Ping, and Qin Sirui

reliable high-performance liquid chromatography–electrospray ionization–tandem mass spectrometry (HPLC–ESI–MS/MS) method was developed for the simultaneous determination of the five active Schisandra lignans in the biological samples. Using this method

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