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and rapid method based on ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) has been developed and validated for the determination of remimazolam and its major carboxylic acid metabolite (M1) in human urine [ 4 ]. The method

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Acta Chromatographica
Authors: Shuanghu Wang, Zixia Lin, Ke Su, Jing Zhang, Lijing Zhang, Zhimou Gao, Zhiyi Wang, Jianshe Ma, and Xianqin Wang

, Germany). Ultra-pure water was prepared by Millipore Milli-Q purification system (Bedford, MA, USA). Instrumentation and Conditions Ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) with

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Acta Chromatographica
Authors: Yongxi Jin, Yuyan Chen, Jiawen Liu, Xi Bao, Yinghao Zhi, Congcong Wen, and Wenzong Zhu

mass spectrometry (UPLC–MS/MS) reported for the determination of ebeiedinone. To the best of our knowledge, the pharmacokinetics of ebeiedinone had not been reported. In this paper, UPLC–MS/MS method was established to determine ebeiedinone in mouse

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Acta Chromatographica
Authors: Jianbo Li, Zheng Yu, Cheng Han, Zhening Wang, Yujie Hu, Congcong Wen, and Chongliang Lin

, distribution, and metabolism, and the bioavailability was greatly improved. Ultra-high performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) combined technology combines the high resolution of liquid chromatography with the high

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of non-metabolized GLM [ 6–9 ]. Also, liquid chromatography-tandem mass spectrometry (LC-MS) has been developed for its determination [ 10–13 ]. Generally, two extraction procedures were used for the recovery of GLM from plasma, including liquid

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mass spectrometry (UHPLC-MS/MS) is an excellent method for the selective and sensitive determination of small molecular weight compounds in biological samples [ 6, 7 ]. Fenofibrate is a prodrug that is hydrolyzed immediately after absorption by tissue

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mass spectrometry (UHPLC-MS/MS) is an excellent method for the selective and sensitive determination of small molecular weight compounds in biological samples [ 6, 7 ]. Fenofibrate is a prodrug that is hydrolyzed immediately after absorption by tissue

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using ultra-high performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS). In the present study, we established a simple, sensitive, and rapid liquid chromatography (LC)–MS/MS method and validated for determination of PH in dog plasma

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chromatography-diode array detector-hyphenated with tandem mass spectrometry (HPLC–DAD–ESI-MS/MS) was performed to investigate the dynamic changes of trifoliate oranges during the different fermentation statues. Multivariate statistical analyses, including

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chromatography-diode array detector-hyphenated with tandem mass spectrometry (HPLC–DAD–ESI-MS/MS) was performed to investigate the dynamic changes of trifoliate oranges during the different fermentation statues. Multivariate statistical analyses, including

Open access