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/mL for evaluating accuracy, precision, and stability. All the solutions were stored at 4 °C until processed. Preparation of Plasma Samples Licochalcone A and IS were simultaneously extracted from the plasma specimens
, linearity, limit of detection (LOD), limit of quantification (LOQ), accuracy, precision and robustness of drug in plasma were assessed. Selectivity The selectivity of developed method was performed by evaluating blank as well as CAP samples The RT was
0.2 mL/min. The nebulizing and drying gas used was nitrogen. Method Validation The proposed method was validated by specificity, linearity range, accuracy, precision, limit of detection (LOD), limit of
samples for the evaluation of intra- and inter-batch precision and accuracy, matrix effect, and stability were 1.5, 30, and 750 ng/mL for remimazolam and 60, 1200, and 30,000 ng/mL for M1, respectively. IS working solutions (100 ng/mL for remimazolam and
Administration (FDA) [ 24 ]. The validation work included selectivity, matrix effect, linearity, precision, accuracy, recovery, and stability. Selectivity of the UPLC–MS/MS method was evaluated by detecting six lots of blank plasma, blank plasma spiked
Method Validation The linear relationship, limit of detection (LOD), limit of quantification (LOQ), recovery, precision, and relative standard deviation (RSD) are shown in Tables 2 , 3 , and 4 to evaluate the quality of this method. The
guidelines [ 14 – 19 ]. Validation projects included selectivity, matrix effects, linearity, precision, accuracy, recovery, and stability [ 20 – 24 ]. The selectivity of the method was evaluated by analyzing 6 lots of different sources of blank
. Method Validation Validation of the method for determination of chlorogenic acid in green coffee was performed testing following parameters: linearity, specificity, selectivity, precision, accuracy, limit of detection (LOD), and limit of
verification method was established in accordance with the US Food and Drug Administration (FDA) bioanalytical method validation guidelines. Validation projects include selectivity, matrix effects, linearity, precision, accuracy, recovery, and stability
/mL. All solutions were stored at 4 °C and brought to room temperature before use. Calibration standards and quality control (QC) samples used to estimate precision and accuracy of the method were prepared from two separate sets of solutions in
