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Journal of Thermal Analysis and Calorimetry
Authors: Luzia Patricia Fernandes Carvalho Galvão, Anne Gabriella Dias Santos, Amanda Duarte Gondim, Marcela Nascimento Barbosa, Antonio Souza Araujo, Luiz Di Souza, and Valter José Fernandes Junior

ethyl esters (the chemical name for biodiesel) [ 7 ]. Although the renewable origin and biodegradability of the biodiesel are widely presented as advantage, its decomposition profile confers to itself lower oxidative stability in comparison to mineral

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irreversible inactivation of proteins. Ligand binding, amino acid composition, hydrophobic interactions, disulfide bonds, salt bridges, and hydrogen bonding influence the protein stability. Recently, boron has been reported to stabilize the structure of heme

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138 Q.A. Xu, L.A. Trissel , Stability-indicating HPLC Methods for Drug Analysis, American Pharmacists Association, Washington, DC, 2003

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Abstract  

The thermodynamic stability of pancreatic ribonuclease B (RNase B), which possesses identical protein structure of pancreatic ribonuclease A (RNase A), but differs by the presence of a carbohydrate chain attached to Asn 34, was studied by means of differential scanning calorimetry (DSC) at different pH conditions. The comparison between the two proteins has shown a little but significant stabilization of RNase B with respect to the unglycosylated one at pH values higher than 7.0. The thermodynamic analysis reveals the carbohydrate moiety to have a small stabilization effect of 3 kJ mol–1 at pH 8.0 and 63°C on the protein.

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A close relation between thermal data and the thermodynamic stability of intermetallic compounds is pointed out. Several series of intermediate phases formed by metals of theA and transition groups with elements of groups IB to IVB have been considered. The dependence of the thermal and thermodynamic stabilities on the atomic size, the electronic configuration, the electronegativity and the melting temperature of the component is discussed.

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stability principles and practice , 2nd edn., Marcel Dekker , New York, NY , 1995 . [5] ICH, Q1A (R2), Stability testing of new drugs and products, International Conference on Harmonization of technical requirements for

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.L. Macdonald 1999 Epilepsia 40 6 769 – 776 . [10]. ICH Stability Testing of New Drug Substances

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ICH Guidelines Q1A (R2) , Stability Testing of New Drug Substances and Products, ICH, Geneva, Switzerland, 2003. Stability Testing of New Drug Substances and Products

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Journal of Thermal Analysis and Calorimetry
Authors: E. F. S. M. Ramalho, A. R. Albuquerque, A. L. Souza, A. K. Barro, A. S. Maia, I. M. G. Santos, and A. G. Souza

Introduction An important problem associated to commercial biodiesel acceptation is its low oxidative stability [ 1 ], which is determined by the nature of the fatty acid chains of oils or fats [ 2 ]. This fact can be evidenced

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://www.rxlist.com/seroquel-drug.htm (Accessed on October 13, 2006). [3]. International Conference on Harmonization (ICH) , Stability Testing of New Drug Substances and Products , Q1A (R2), IFPMA, Geneva, Switzerland, 2003

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