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A nyelőcsőrák a hatodik leggyakoribb daganatos halálok, gyakorisága nő. A nyelőcsőrákok 95%-a laphámrák vagy adenocarcinoma. Bár a nyelőcsőlaphámrák és az adenocarcinoma szövettana és előfordulása különböző, számos kockázati tényezőjük (dohányzás, táplálkozási szokások), valamint a daganatkialakulás folyamata hasonló. A nyelőcsőrák több mint 90%-ban előrehaladott állapotban derül ki. A felismerés és a kezelés lehetőségeinek fejlődése ellenére kórjóslata rossz, az ötéves túlélés 10–13%. A kórélettani háttér pontosabb megértése a megelőzést segítheti, részben természetes hatóanyagok, részben nemszteroid gyulladáscsökkentők alkalmazásával.

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Orvosi Hetilap
Authors: Boglárka Brúgós and Margit Zeher

A szisztémás lupus erythematosus poliszisztémás autoimmun betegség, egyik legjelentősebb szervi szövődménye a lupus nephritis. A lupus nephritis időbeni, a krónikus szervi érintettség kialakulását megelőző felismerése, a shubok előrejelzése, a korai agresszív kezelés elkezdése és a terápia sikerességének lemérése kívánatos lenne. Ezért a kutatások egy része intenzíven a legmegfelelőbb, aktivitást előre jelző biomarker megtalálására irányul. Jelen összefoglaló célja a hagyományos szerológiai markerek megbeszélésén túl a legújabb, részben még kísérletes, a klinikai gyakorlatban nem használt, de az SLE, illetve lupus nephritis aktivitását jellemző specifikus biomarkerek bemutatása.

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The activity of microorganisms plays a very important function in the whole spectrum of degradation processes such as corrosion of metals and concrete, the plugging of the pipeline and filters in consequence of the biofilms creation or the efficiency reduction of heat exchangers. The microorganisms that cause microbiologically influenced corrosion of concrete are ubiquitous in the environment and they produce either organic or inorganic acids that can dissolve and disintegrate the concrete matrix. This paper is focused on the concrete biocorrosion’s study in real sulfuretum conditions — in a sewer pipe with wastewater in Košice city. Concrete samples with addition of 5 and 10% of coal fly ash respectively as well as reference samples without coal fly ash addition were used for the experiment. The weight changes and surface changes of concrete samples were valuated after 4-month exposition to the real sulfuretum influence. The concrete biodeterioration studies in sewer pipes suggest the analogical biodegradation processes for all samples, whereby the composition of concrete and duration of aggressive environment influence are also important.

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At the heart of Carl Dahlhaus’s historiographic interests, according to James Hepokoski, was an “effort to keep the Austro-German canon from Beethoven to Schoenberg free from aggressively sociopolitical interpretations.” But Dahlhaus did not stop at Schoenberg: he also wrote about postwar music, and one might therefore wonder whether his “Austro-German canon” of autonomous music extended past 1945. In his essays on this period, Dahlhaus claimed that the postwar musical avant-garde was defined by the concept of the experiment, a concept that was, he believed, “nothing less than the fundamental aesthetic paradigm of serial and post-serial music.” He maintained this view from the 1960s through the 1980s, and thereby placed the concept of the experiment at the center of his historiography of postwar music. My paper shows that the concept of the experiment, as defined by Dahlhaus, has a uniquely German pedigree, one that is not at odds with his wider historiographic interests. By making the concept of the experiment central to his account of postwar music, Dahlhaus was thereby able to extend his historiography beyond the canon that ran from Beethoven to Schoenberg and include also later composers. In so doing, he lent the supposedly “international” postwar avant-garde a character that seems specifically German.

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Taxonomy of law and legal mapping

Patterns and limits of the classification of legal systems

Acta Juridica Hungarica
Author: Csaba Varga

Attempts from the 17th century onward anticipate the 20th-century mood of legal mapping. They classify legal arrangements by languages, races and genetic roots, then by their ideologies and technicalities. Later on they do so by separating the Western from the Soviet/socialist law, by their correspondence to underlying general cultures, as well as according to legal families. It is the insufficiency of resorting to dichotomy contrasting the Western “Us” to any differing Eastern “Others” that has recently resulted in typologising in terms of the dynamism and directions of legal development in the duality of professionalism and traditionalism or in the cross-reference of what is established/stable and unestablished/instable, and of what is drawn from Western and non-Western sources. Material taxonomy cannot be accomplished in law through genuine class-concepts. Characterisation through concepts of order can be achieved at most. In want of any meta-system, cultures formed to idealise and hypostasise ideas of order by independent principles can provide no common basis of division for law. Accordingly, only some division to major and minor sets and subsets can be achieved. The own arrangement will be better cognised by other schemes’ understanding. The gradual transcendence of rule-fetishism by identifying law with some specific culture may prevent the coming “clash of civilizations” from reaching aggressive self-assertion and care for the sustainability of the laws’ diversity.

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Imaging
Authors: Borbála Vattay, Melinda Boussoussou, Sarolta Borzsák, Milán Vecsey-Nagy, Judit Simon, Márton Kolossváry, Béla Merkely, and Bálint Szilveszter

Abstract

Combined anatomical and functional evaluation of coronary artery disease (CAD) using computed tomography (CT) has recently emerged as an accurate, robust and non-invasive tool for the evaluation of ischemic heart disease. Cardiac CT has become a one-stop-shop imaging modality that allows the simultaneous depiction, characterization and quantification of coronary atherosclerosis and the assessment of myocardial ischemia. Advancements in scanner technology (improvements in spatial and temporal resolution, dual-energy imaging, wide detector panels) and the implementation of iterative reconstruction algorithms enables the detection of myocardial ischemia in both qualitative and quantitative fashion using low-dose scanning protocols. The addition of CT perfusion (CTP) to standard coronary CT angiography is a reliable tool to improve diagnostic accuracy. CTP using static first-pass imaging enables qualitative assessment of the myocardial tissue, whereas dynamic perfusion imaging can also provide quantitative information on myocardial blood flow. Myocardial tissue assessment by CTP holds the potential to refine risk in stable chest pain or microvascular dysfunction. CTP can aid the detection of residual ischemia after coronary intervention. Comprehensive evaluation of CAD using CTP might therefore improve the selection of patients for aggressive secondary prevention therapy or coronary revascularization with high diagnostic certainty. In addition, prognostic information provided by perfusion CT imaging could improve patient outcomes by quantifying the ischemic burden of the left ventricle. The current review focuses on the clinical value of myocardial perfusion imaging by CT, current status of CTP imaging and the use of myocardial CTP in various patient populations for the diagnosis of ischemic heart disease.

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Words like aggression, violence, and violent actions usually carry destructive meanings. People tend to forget their constructive culturally determined meanings. In spite of this, it can be argued that aggressive feelings, hatred, anger, verbal aggression, threatening behaviour, assault, inflicting pain, injuring or ritual killing of men, or the fighting of war are all part of our lives as much as feasts and rituals that bind communities together, or the command to love of different religious ideologies. In the 16th century there was a definitive turn in judging the body in public. It meant that public attention gradually turned from the corpse of Christ to the bodies of the thieves. The two thieves were brought down from their crosses, laid out on the dissecting table, or their bodies were torn apart during fights. Evil-doers became part of scientific cognition. The antisocial public enemy became a hero of the community in the popular literature and historic stories. The conserved and stuffed bodies of robbers and killers were displayed in the first museums of the Early Modern Age, as a main attraction. Rebels were cut into pieces as part of a baroque play on the killing floor to display the parts in buildings of the town. The body of the everyday killer became a spectacle, and the interest in the mind of the solitary killer developed medical thinking on the human spirit.

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. et al. ( 2012 ): Validation of a modified Petri-dish test to quantify aggressiveness of Fusarium graminearum in durum wheat . Eur. J. Plant Pathol. 132 , 381 – 391 . Romero , C. C. T. , Vermeulen , J. P. , Vels , A. et al. ( 2018

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Kull, L. S., Palmquist, D. and Hartman, G. L. (2004): Mycelial compatibility and aggressiveness of Sclerotinia sclerotiorum . Plant Disease 88, 325-332 Mycelial compatibility and aggressiveness of Sclerotinia sclerotiorum

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Orvosi Hetilap
Authors: János László Iványi, Éva Marton, Márk Plander, Zoltán Vendel Engert, and Csaba Tóth

Bevezetés: A primer herelymphoma ritkán előforduló extranodalis non-Hodgkin-lymphoma-entitás. Legtöbbször idős férfiakban fordul elő, nagy malignitású szövettani képpel és kedvezőtlen kórlefolyással. Az érintett here eltávolítása után alkalmazott immunkemoterápia ellenére a betegek kezelési eredményei elmaradnak más extranodalis lymphomásokétól. Célkitűzés: Retrospektív felmérésben a szerzők célul tűzték ki 2000 és 2012 között kórismézett és kezelt herelymphomás betegeik klinikopatológiai és kezelési eredményeinek felmérését. Módszer: Ezen időszak alatt 334 agresszív non-Hodgkin-lymphomás betegből nyolc esetben (8/334, 2,39%) kórisméztek primer herelymphomát (diffúz nagysejtes B-sejtes hét esetben, Burkitt-típusú egy esetben). A betegek medián életkora 60 év (23 és 86 év között) volt. Korai I–IIE hét betegben, előrehaladott stádium egy betegben fordult elő. Egy beteg kivételével (csak radioterápia) minden beteg kemoterápiát kapott (rituximab+CHOP, hat–nyolc ciklus 21 vagy 28 naponként). Mindössze egy beteg részesült központi idegrendszeri kemoterápiás profilaxisban, preventív ellenoldali hereirradiációt nem alkalmaztak. Eredmények: Ötven hónapos medián követés alatt semicastratiót követő rituximab- és CHOP-kúra után hét beteg került komplett remisszióba, két beteg elhunyt (egy beteg a lymphoma progressziója következtében, a remisszióban levő másik beteg szekunder tüdőtumor miatt). Komplett remissziót a betegek 87,5%-ában értek el. A betegségmentes túlélés 13–152 hónap között (medián 38 hónap), az összesített túlélés 17–156 hónap között (medián 43 hónap), az ötéves betegségmentes és összesített túlélés pedig egyaránt 37,5% volt. Következtetések: A viszonylag kedvező kezelési eredmények hátterében a korai stádium túlsúlya, a lymphoma urológiai sebészi eltávolítása, az immunkemoterápia hatásossága, illetve a közeli és távoli (idegrendszeri) relapsus hiánya állhat. Orv. Hetil., 2013, 154, 1666–1673.

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