data set. RSM searches for numerical reasons for the behavior of a data set. It can be applied very well in situations where multiple variables influence an answer. The method's aim is to optimize these variables simultaneously in order to achieve the
Authors:Jovana Tomić, Nevena Djajić, Danica Agbaba, Biljana Otašević, Andjelija Malenović, and Ana Protić
industry [ 15, 16 ]. Quality by Design (QbD) has been utilized for more than a decade and labeled as AQbD when applied in the area of analytical method development [ 15, 16 ]. Analytical target profile (ATP) must be defined prior to the optimization process
Authors:M. Hernández-Escolano, X. Ramis, A. Jiménez-Morales, M. Juan-Díaz, and J. Suay
stabilizes the network formed by sol–gel process specially when its content is 5% wt.
In order to optimize the curing procedure for hybrid systems to obtain Si networks with or without organic chains, a thermal
Differential scanning calorimetry (DSC) was used
to establish criteria for optimization of raw material selection, roasting
process, eating quality, visual appearance, and shelf-life extension of peanuts
[1-4]. DSC methods were developed as both predictive and analytical
tools to define process operating guidelines and to correlate with traditional
quality attributes of roasted peanuts [1-4].
Authors:Hebatallah M. Essam, Martin N. Saad, Eman S. Elzanfaly, and Sawsan M. Amer
under analysis of laboratory prepared mixtures was followed to determine the concentration of each drug in the dosage form. 3 Results and discussion 3.1 Method optimization For HPLC The main criteria for development of a successful HPLC method is its
Authors:Iisa Outola, Kenneth Inn, Robert Ford, Steve Markham, and Petri Outola
The environmental mobility/availability behavior of radionuclides in soils and sediments depends on their speciation. Experiments
have been carried out to develop a simple but robust radionuclide sequential extraction method for identification of radionuclide
partitioning in sediments and soils. The sequential extraction protocol was optimized for temperature, concentration of reagents
and reaction time. Optimum extraction conditions were chosen based on the release of 239,240Pu, 238U and stable elements. Results from the experiments with lake sediment (SRM 4354) are compared to the previous trials where
the sequential extraction protocol was optimized with the ocean sediment (SRM 4357). Based on these two trials the NIST standard
sequential extraction protocol is established for defined extraction settings for temperature, reagent concentration and time.
k0-NAA allows the simultaneous analysis of up-to 67 elements. Thek0 method is based on calculations using a special library instead of measuring standards. For an efficient use of the method,
the calculations and resulting raw data require optimized evaluation procedures. In this paper two efficient procedures for
nuclide identification and gamma interference correction are outlined. For a fast computation of the source-detector efficiency
and coincidence correction factors the matrix interpolation technique is introduced.
A ternary mobile phase for thin-layer chromatographic separation and identification of seven amino acids on microcrystalline cellulose, with ninhydrin as detection reagent, has been optimized by use of the experimental design software packages
. When the results from each product were compared the optimum mobile phase was found to be butanol-glacial acetic acid-water 60.14:18.77:21.09. The performance of this mobile phase was confirmed experimentally.