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Acta Veterinaria Hungarica
Authors: Andrea Győrffy, Mónika Keresztes, Vera Faigl, Vilmos Frenyó, Margit Kulcsár, Tibor Gaál, Miklós Mézes, Attila Zsarnovszky, Gyula Huszenicza, and Tibor Bartha

In the regulation of energy metabolism, the liver plays an important role in the reinforcement of energy production. In periparturient cows the energy homeostasis turns into a negative energy balance that may shift the physiological regulation of energy balance towards pathological processes. Propylene glycol (PG), as a complementary source of energy used in the nutrition of dairy cows, alters systemic thyroid hormone economy; however, the exact mechanism through which highly glycogenic feed supplements impact liver metabolism is little known. Previous studies showed that only leptin receptors are expressed in the liver of cows, and now we report that leptin mRNA is expressed in the liver of cows as well. The present results show that the mRNA of leptin and its receptors are differentially modulated by the increased energy content of the feed consumed. Simultaneous changes in hepatic type I deiodinase activity suggest that hepatic modulation of the leptin system by PG supplementation may be mediated by an increased local thyroxine-triiodothyronine conversion. Since PG supplementation with simultaneous T4–T3 turnover and increased hepatic leptin- and short-form leptin receptor mRNA were not associated with a significant change in hepatic total lipid levels, it is suggested that the leptin system, directly or indirectly modulated by thyroid hormones, may represent a local defence mechanism to prevent fatty liver formation.

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Hematológia–Transzfuziológia
Authors: Petra Kövy, András Kozma, András Bors, Nóra Meggyesi, Emma Ádám, Adrienn Borsy, János Dolgos, Nóra Lovas, József Harasztdombi, Viktor Lakatos, István Vályi-Nagy, Gábor Mikala, Péter Reményi, and Hajnalka Andrikovics

TET2 in myeloid cancers. N Engl J Med. 2009; 360(22): 2289–2301. 5 Ito S, D’Alessio AC, Taranova OV, et al. Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self

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perforated duodenal ulcers. Surg Gynecol Obstet 1937; 64: 235–238. 52 Zimmermann M, Hoffmann M, Laubert T, et al.: Conversion of laparoscopic surgery for

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Magyar Onkológia
Authors: György Lázár, Attila Paszt, Zsolt Simonka, Richárd Rokszin, and Szabolcs Ábrahám

colectomy: indications for conversion to laparotomy Arch Surg 134 471 475 . 26. J Pfeifer

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. 1999 77 671 679 Prasad, S., Raj, J., Bhalla, T. C.: Bench scale conversion of 3-cyanopyridine to nicotinamide using

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H Toy 2006 Sex as a factor in conversion from laparoscopic cholecystectomy to open surgery JSLS 10 359 63

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The biological properties of bovine viral diarrhoea virus (BVDV) strain Oregon C24V were studied after intranasal and subcutaneous infection of pregnant sows. This virus strain is widely used in Hungary for immunising cattle against bovine viral diarrhoea (BVD). Based upon the results of the clinical, gross pathological, histopathological and virological examinations it can be established that the given strain caused asymptomatic infection and serological conversion in sows that were in the second third of gestation. The virus caused clinically apparent disease in some of the piglets born at term, which indicates that it had crossed the placenta. More than half (57%) of the live-born piglets died within 60 days of birth. The sows and their progeny did not shed the virus. BVDV infection has great differential diagnostic importance in pigs, as classical swine fever (CSF) virus strains of reduced virulence cause similar clinical symptoms and gross and histopathological changes.

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Magyar Sebészet
Authors: Pál Gehér, Árpád Füredi, László István Kecskés, and Béla Kiss

Absztrakt

Célkitűzés: A szerzők az általuk a Markusovszky Egyetemi Oktatókórház Mellkassebészeti Osztályán 2010 decembere óta elvégzett videoendoszkópos tüdőlebeny-reszekciók (VATS-lobectomia) tapasztalatait elemzik. Betegek és módszer: 78 beteg (44 férfi és 34 nő) esett át VATS-lobectomián. A legfiatalabb beteg 30, a legidősebb 80 éves, az átlagéletkor 61,2 év volt. A műtéti indikáció perifériás tüdődaganat (35 eset) vagy annak gyanúja (43 eset) volt, kezelhető távoli áttét jelenléte nem jelentett kontraindikációt. Eredmények: A kezdetben igen hosszú műtéti idő csökkent és közelített a thoracotomiából végzett lobectomiákéhoz. Késői reoperációra két esetben volt szükség krónikus légmell, illetve „port site” metasztázis miatt. A bekövetkezett 10 érsérülés és két hörgősérülés miatt nyolc alkalommal volt szükség a feltárás axillaris thoracotomiává alakítására (konverziós ráta: 10,26%). A műtét utáni időszak az így operált betegek számára jelentősen kisebb fájdalmakkal járt, mint a nyitott műtétek utáni. Következtetések: A VATS-lobectomia biztonságosan alkalmazható, a betegek számára kisebb megterhelést jelentő módszer onkológiai kompromisszum nélkül.

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Orvosi Hetilap
Authors: Ádám Remport, Dávid Dankó, Zsuzsa Gerlei, Krisztina Czebe, and István Kiss

Roza, A., Tomlanovich, S., Merion, R., et al.: Conversion of stable renal allograft recipients to a bioequivalent cyclosporine formulation. Transplantation, 2002, 74 , 1013–1017. Merion R

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This study assessed the preventive effects of arginine (ARG) and guanidinoacetic acid (GAA) on the incidence of pulmonary hypertension syndrome (PHS) in broiler chickens. Four isoenergetic and isonitrogenous diets were prepared, including: (i) the control, (ii) the control supplemented with 1 g/kg ARG, (iii) the control supplemented with 1 g/kg GAA, and (iv) the control supplemented with 1.5 g/kg GAA. These diets were fed to broilers (Ross 308) from day 1 to 42 post-hatch. Criteria evaluated in the experiment were growth performance, carcass characteristics, serum and blood variables, lead-II electrocardiogram, and ET-1 and iNOS gene expression in heart and lungs. Mortality from PHS was recorded daily. The results showed that ARG and GAA supplements improved the feed conversion ratio (FCR) compared to the control (P < 0.05). Supplementation of ARG and GAA significantly (P < 0.05) increased serum nitric oxide (NO) concentration. ARG and GAA supplementation significantly reduced the haematocrit value and the heterophil to lymphocyte ratio in the blood. A significant (P < 0.05) decline in S-wave amplitude of the lead-II electrocardiogram, right to total ventricular weight ratio (RV:TV) and ascites mortality was observed by supplementing ARG or 1.5 g/kg GAA. Addition of ARG and GAA supplements did not significantly change ET-1 and iNOS gene expression in the heart and lung relative to the control. In conclusion, GAA supplementation at 1.5 g/kg had a potential to improve growth performance and could prevent PHS.

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