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Green, P. K., Wilkinson, C. W., Woods, S. C. (1992) Intraventricular corticosterone increases the body weight gain in underweight adrenalectomised rats. Endocrinol. 130 , 269

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144 Kotrschal, K., Dittami, J., Hirschenhauser, K., Mostl, E., Peczely, P. (2000) Effects of physiological and social challenges in different seasons on fecal testosterone and corticosterone

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. M., Andrew, R., Kenyon, C. J., Walker, B. R. (2000) Understanding the role of glucocorticoids in obesity: tissue-specific alterations of corticosterone metabolism in obese Zucker rats. Endocrinology 141, 560

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Davis, G. S., Anderson, K. E., Carroll, A. S. (2000) The effects of long-term caging and molt of Single Comb White Leghorn hens on heterophil to lymphocyte ratios, corticosterone and thyroid hormons. Poultry Sci. 79 , 514

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Acta Biologica Hungarica
Authors: Khadiga G. Adham, Manal H. Farhood, Maha H. Daghestani, Nadia A. Aleisa, Ahlam A. Alkhalifa, Maha H. El Amin, Promy Virk, Mai A. Al-Obeid, and Eman M. H. Al-Humaidhi

One of the common causes of iron overload is excessive iron intake in cases of iron-poor anemia, where iron saccharate complex (ISC) is routinely used to optimize erythropoiesis. However, non-standardized ISC administration could entail the risk of iron overload. To induce iron overload, Wistar rats were intraperitoneally injected with subacute (0.2 mg kg−1) and subchronic (0.1 mg kg−1) overdoses of ISC for 2 and 4 weeks, respectively. Iron status was displayed by an increase in transferrin saturation (up to 332%) and serum and liver iron burden (up to 19.3 μmol L−1 and 13.2 μmol g−1 wet tissue, respectively) together with a drop in total and unsaturated iron binding capacities “TIBC, UIBC” as surrogate markers of transferrin activity. Iron-induced leukocytosis (up to 140%), along with the decline in serum transferrin markers (up to 43%), respectively, mark positive and negative acute phase reactions. Chemical stress was demonstrated by a significant rise (p > 0.05) in indices of the hemogram (erythrocytes, hemoglobin, hematocrit, leukocytes) and stress metabolites [corticosterone (CORT) and lactate]. Yet, potential causes of the unexpected decline in serum activities of ALT, AST and LDH (p > 0.05) might include decreased hepatocellular enzyme production and/or inhibition or reduction of the enzyme activities. The current findings highlight the toxic role of elevated serum and liver iron in initiating erythropoiesis and acute phase reactions, modifying iron status and animal organ function, changing energy metabolism and bringing about accelerated glycolysis and impaired lactate clearance supposedly by decreasing anaerobic threshold and causing premature entering to the anaerobic system.

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Cohen, A. (1973) Plasma corticosterone concentration in the fetal rat. Horm. Metab. Res. 5 , 66. Plasma corticosterone concentration in the fetal rat Horm

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47 37 42 O’Malley, J., Dambrosia, J. M., Davis, J. A. (2008) Effect of housing density on reproductive parameters and corticosterone levels in

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Acta Biologica Hungarica
Authors: V. Posevitz, C. Vizler, S. Benyhe, E. Duda, and Anna Borsodi

411 420 Pruett, S. B., Fan, R. (2001) Quantitative modeling of suppression of IgG1, IgG2a, IL-2, and IL-4 responses to antigen in mice treated with exogenous corticosterone or

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Gruber, J., Sgone, R., Hu, Y. H., Beng, H., Wick, G. (1994) Thymocyte apoptosis by elevated endogenous corticosterone level. Eur. J. Immunol. 24 , 1115-1121. Thymocyte apoptosis by elevated endogenous corticosterone level

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., Maier, S. F., Watkins, L. R. (1998) Thermogenic and corticosterone responses to intravenous cytokines (IL-lbeta and TNF-alpha) are attenuated by subdiaphragmatic vagotomy. J. Neuroimmunol. 86 , 134-141. Thermogenic and

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