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Drasch, G., Wanghofer, E. and Roider, G. (1997): Are blood, urine, hair, and muscle valid biomonitors for the internal burden of men with the heavy metals mercury, lead and cadmium? Trace Elements and Electrolytes 14 , 116

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Interventional Medicine and Applied Science
Authors: Alexey Tymoshenko, Gennadii Tkach, Vitalii Sikora, Valentina Bumeister, Ihor Shpetnyi, Mykola Lyndin, Olena Maksymova, and Anna Maslenko

effect on all biological species [1] . Direct or indirect intake of different contaminants can cause a disease or become a reason for the development of related disorders [2, 3] . Heavy metals are considered to be terribly dangerous for their

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Interventional Medicine and Applied Science
Authors: Anatolii Romaniuk, Vladyslav Sikora, Mykola Lyndin, Vladyslav Smiyanov, Volodymyr Sikora, Yulia Lyndina, Artem Piddubnyi, Nataliya Gyryavenko, and Anna Korobchanska

into biosphere is comprised of heavy metal salts (HMS). The prevalence and toxicity of these metals pose a significant problem to many countries [ 3, 4 ]. Unfortunately, because of the increase in day-to-day pollution by various emissions, ecological

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. Shafran LM , Bolshoy DV , Loburenko AP : Age distinctions in heavy metals toxicity (system approach) . Toxicol Lett 123 ( 1 ), 52 ( 2001 ) 4

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Acta Veterinaria Hungarica
Authors: A. Bersényi, S. Fekete, I. Hullár, I. Kádár, M. Szilágyi, R. Glávits, Margit Kulcsár, M. Mézes, and L. Zöldág

Kádár , I. ( 1995 ): Serum magnesium level and certain biochemical parameters in chicken and rabbits fed normal and heavy metals containing rations . Proc. Soc. Nutr. Physiol. 4 , 90 – 98 .

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Interventional Medicine and Applied Science
Authors: Anatolii Romaniuk, Mykola Lyndin, Roman Moskalenko, Yevhen Kuzenko, Oksana Gladchenko, and Yuliia Lyndina

Materials and Methods: Chemical composition was studied with the help of the scanning electron microscope with energy-dispersion spectrometer. Immunohistochemical reaction showed the p53 and Ki-67 receptors expression. The study of DNA fragmentation was performed in agarose gel. Results: There was an interrelation between the accumulations of the trace elements with the degree of cancer malignancy. There were 85% of cases with positive reaction to Ki-67 and 40% cases with positive reaction to p53. We found a moderate correlation between the accumulation of microelements in the breast cancer tissue and the level of proliferative activity. We noted the combination of the increase of DNA fragmentation with the expression of p53 and Ki-67 receptors. Conclusions: The trace elements can cause the initiation and the progression of the tumorous growth, which is expressed in the increased proliferation of tumor cells. This leads to the destabilization of the genetic material which can be expressed in the synthesis of mutant p53 protein. Finally, it leads to the block of apoptosis and regulatory effects of cells. This can cause the tumor progression and the destabilization of the genome, which is reflected in the increased DNA fragmentation.

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Leucoc Biol 35 192 208 Klaassen, C. D.: Heavy metals and heavy metal antagonists. In: Gilman, A. G. et al

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Acta Veterinaria Hungarica
Authors: József Lehel, János Gál, Sándor Faragó, Erzsébet Berta, Emese Andrásofszky, Sándor Fekete, Míra Mándoki, Péter Budai, Éva Kormos, and Miklós Marosán

Honda, K., Yamamoto, Y., Hidaka, H. and Tatsukawa, R. (1986): Heavy metal accumulations in Adélie penguin, Pygoscelis adeliae , and their variations with the reproductive processes. Pol. Res. Series 40 , 443

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Potato and beetroot were grown on soils previously treated with heavy metal salts. Each particular microelement had a high concentration in both potato and beetroot [cadmium (Cd) 3.7 and 55.4, lead (Pb) 8.1 and 3.0, and mercury (Hg) 5.8 and 6.8 mg/kg dry matter, respectively]. In a metabolic balance trial 16 New Zealand White rabbits were fed 50 grams of basal diet and potato or beetroot ad libitum. The apparent digestibility of major nutrients and the accumulation of the microelements in different organs were investigated. Both potato and beetroot samples of high Pb and Hg content had the significantly (p < 0.05) lowest digestibility of organic matter and nitrogen-free extract. The Cd ingested from both potato and beetroot accumulated in the kidneys and liver (2.85 and 1.48 as well as 0.459 and 0.265 mg/kg, respectively). All the microelements (Cd, Pb and Hg) accumulated in the testicles (0.196, 0.32 and 0.199 mg/kg, respectively), reducing the rate of spermatogenesis. The tissue retention ofheavy metals depends not only on the element itself, but also upon the ‘carrier’ feedstuff.

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. Eng. 47 , 1288 – 1293 . Dzugan , M. , Zielinska , S. , Heclik , J. , Pieniazek , M. and Szostek , M. ( 2012 b): Evaluation of heavy metals environmental contamination

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