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smoking. The aim of the present study was to investigate the influence of maternal smoking during pregnancy on the early physical and neurobehavioral development of newborn rats. Our hypothesis was that maternal smoking during pregnancy interferes with

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Newborn rats of both sexes were treated (imprinted) with 20mg of benzpyrene. Two hours, 2 days, 1, 2, 3 weeks, 1 month and 2 months after imprinting the liver glucocorticoid receptors were studied for binding of dexamethasone. Two-hour and 2-day values were not appreciable. One week after treatment the receptor's affinity was extremely low both in control and treated treated animals. Two weeks after imprinting a significant difference in density (lower) and affinity (higher) was observed between the male treated and control animals. At 3 weeks and one month the binding capacity of treated and control animals was equal however, at 2 months Bmaxof males increased and that of females decreased significantly in the neonatally benzpyrene treated animals. This means that for the development of perinatal imprinting effect a long time is needed, and the effect is manifested after a period of lability.

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In earlier experiments single benzpyrene treatment of newborn rats caused strong alterations in the endorphin content of adult rats' immune cells. In the present experiments young (4-6 weeks old) male rats were studied for demonstrating the effect of the single neonatal or repeated (neonatally and at weanling) benzpyrene exposure on the serotonin content of immune cells (blood lymphocytes, monocytes, granulocytes; peritoneal fluid lymphocytes, mast cells, monocytes and granulocytes, thymic lymphocytes). Flow cytometric analysis showed that 50 µg benzpyrene treatment of five-week-old animals was ineffective after 5 days and this was the situation four weeks after single neonatal (20 µg) benzpyrene exposure. However, the repeated treatment of neonatally benzpyrene exposed 4 weeks old animals after 5 days resulted in elevated blood and thymic lymphocyte serotonin amount and in one index (peritoneal monocyte-granulocyte group) reduced serotonin content. This means that neonatal benzpyrene treatment does not influence directly the serotonin content (production or transport) of immune cells (unlike to the endorphin content) however, sensitizes them to a following benzpyrene exposure. The results widen the list of harmful effects (influencing steroid receptor binding, sexual behavior and immune cells' endorphin content) of perinatal benzpyrene exposure.

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. J., et al.: Glucagon-like-peptide-1 and exendin-4 stimulate β-cell neogenesis in streptozotocin-treated newborn rats resulting in presistenly improved glucose homeostasis at adult age

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1991; 66: 153–156. 36 Nagy SU, Csaba G. Dose dependence of the thyrotropin (TSH) receptor damaging effect of gonadotropin in the newborn rats. Acta Physiol Hung. 1980; 56: 417

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., Gyenge, M., Hantos, M., et al.: Transgenerational hormonal imprinting caused by vitamin A and vitamin D treatment of newborn rats. Alterations in the biogenic amine contents of the adult brain. Brain Dev., 2009

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of TSH and gonadotropin pretreatment (hormonal imprintig) of newborn rats on hormonal overlap in adult animals. Acta Physiol Hung. 1983; 61: 205–211. 10

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58 41 50 Pállinger, É., Kovács, P., Csaba, G.: Presence of hormones (triiodothyronine, serotonin and histamine) in the immune cells of newborn rats

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. 24 407 414 Csaba G, Kovács P, Pállinger É: Single treatment (hormonal imprinting) of newborn rats with serotonin increases the serotonin content of

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23 1547 1558 Franchi G, Veronesi C: Long-term motor cortex reorganization after facial nerve serving in newborn rats. Eur. J. Neurosci. 20(7), 1885

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