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Journal of Behavioral Addictions
Authors: Thomas Mclaughlin, Marlene Oscar-Berman, Thomas Simpatico, John Giordano, Scot Jones, Debmayla Barh, William B. Downs, Roger L. Waite, Margaret Madigan, Kristina Dushaj, Raquel Lohmann, Eric R. Braverman, David Han, and Kenneth Blum

Abstract

Background and aims

Many patients presenting multiple behaviors including drug and food abuse as well as other pathological repetitive unwanted activities such as gambling, self-mutilation and paraphilias may not be appropriately diagnosed. Here we present a case of a male presenting many of these seemingly diverse behaviors and finally diagnosed with reward deficiency syndrome (RDS) by his attending physician.

Methods

The use of the dopamine agonist, ropinirole after two weeks showed improvement in terms of sexual behavior but tolerance set in and was discontinued especially when an infraction occurred with the patient's insurance. In this article, we carefully explore the potential of ropinirole to downregulate dopamine receptors causing adenylate cyclase receptor supersensitivity and tolerance a feature of neurotransmitter cross-talk. Based on previous scientific evidence showing KB220Znutrigenomic amino-acid therapy (NAAT) to rapidly (post one-hour) activate dopaminergic pathways in both the pre-frontal cortex cingulate gyrus (relapse loci) and ventral tegmental area-caudate-accumbens-putamen (craving and emotion loci) the patient was prescribed NAAT.

Results and discussion

Within one week of utilization the repetitive paraphilia was eliminated. There were also a number of other positive effects such as enhanced focus that persisted even after the patient stopped using KB220Z suggesting neuroplasticity (e.g. altruistic thoughts). However, these observed profound benefits require more in-depth study, especially in a large cohort against a placebo. While this report focused on a rapid response rather than long-term benefits previously associated with NAAT, it is somewhat encouraging and longer term required follow-up and larger placebo controlled studies are warranted before any definitive conclusions could be gleaned from this case report.

Open access
Journal of Psychedelic Studies
Authors: Robert Beckstead, Bryce Blankenagel, Cody Noconi, and Michael Winkelman

including Sibly, Scot, Agrippa, and Barrett ( Quinn, 1998 , p. 118). Quinn characterizes these occult books of “enormous significance” to the Smith family, especially Joseph Jr. whose cane was inscribed with symbols from The Magus conveying the message

Open access