Authors:E. Rapavi, R. González-Cabello, K. Szentmihályi, E. Székely, and A. Blázovics
Free radical production and disturbance in the redox status may modulate the expression of a variety of immune and inflammatory molecules. Antioxidants could inhibit the proliferation of T lymphocytes induced by mitogens. The aim of this study was to investigate the effect of the infusion of dried calyx of Hibiscus sabdariffa L. on T-cell-mediated immune response. We examined the effect of the infusion on spontaneous and mitogen-induced blast transformation of human lymphocytes in vitro. Peripheral blood lymphocytes from heparinised venous blood of healthy subjects (n=17) were examined. Five and 10 mg ml-1 phytohemagglutinin (PHA) and 5 mg ml-1 pokeweed mitogen (PWM) were added. Depending on the concentration, calyx infusion of H. sabdariffa decreased mitogen-induced blastogenesis in normal subjects. It did not affect, however, the level of spontaneous proliferation of human lymphocytes in vitro. The infusion of hibisci flos may alleviate over-stimulated condition of the immune system in hypersensitivity conditions.
Authors:F. Békés, K. Ács, Gy. Gell, Cs. Lantos, A-M. Kovács, Zs. Birinyi, and J. Pauk
, R.P. , Degano , P. , Godkin , A.J. , Jewell , D.P. & Hill , A.V.S. ( 2000 ): In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A gliadin T-cell epitope