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Abstract  

The fate of acetochlor herbicide was investigated in corn /Zea mays L./ in nutrition solution culture experiments with and without R-25788 antidote. The antidote was found to slightly stimulate tthe absorption but retard the translocation of acetochlor labelled with14C in the carbonyl group. The degradation of the herbicide and the formation of the acetochlor GSH conjugate were faster in the antidote treated plants than in the untreated controls.

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JPC - Journal of Planar Chromatography - Modern TLC
Authors: Tamás Csermely, Georg Petroianu, Kamil Kuca, Józsel Fűrész, Ferenc Darvas, Zsolt Gulyás, Rudolf Laufer, and Huba Kalász

Quaternary pyridinium aldoximes have been analyzed by thin-layer chromatography. Their separation was adequate when silica plates were used with a mobile phase with a high water content. As a consequence of their limited migration, reversed-phase TLC was not appropriate for determination of the lipophilicity of quaternary pyridinium aldoximes. Displacement TLC of some quaternary pyridinium aldoximes is, nevertheless, possible using silica as stationary phase with water-acetone-hydrochloric acid mobile phases. Normal-phase TLC with different concentrations of organic modifier gave a series of R M values for the pyridinium aldoximes. Approximation of the different plots of R M against organic modifier concentration to straight lines afforded R M,0 values and the slopes of the lines. The R M,0 values and the slopes both serve as indicators of the hydrophilic character of the compounds.

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an efficient antidote would be imperative. Unfortunately, the effectiveness of current treatment protocols is unpredictable due to the weak effect of atropine on the central nervous system and the poor pharmacokinetic properties of the available

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Acta Chromatographica
Authors: S.M. Nurulain, S. Ojha, S. Dhanasekaran, K. Kuča, N. Nalin, C. Sharma, A. Adem, and H. Kalász

Distribution of K027, a hydrophilic, positively charged compound is monitored in the body of pregnant mice using high-performance liquid chromatography (HPLC). Intraperitoneal injection was done on the 18th day of pregnancy; the plasma and brains of the mother mice, placentae and the fetuses’ brains were dissected following 5, 15, 30, 60, and 120 min of treatment. Significant incorporation of K027 was found in the placentae and in fetuses’ brains relative to its levels in the mothers’ plasma and brains. This incorporation warns of a possible adjustment of dose of pyridinium aldoxime antidotes in case of pregnancy. Further studies with different gestational periods and animal models are warranted.

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Acta Chromatographica
Authors: S. M. Nurulain, H. Kalász, P. Szegi, K. Kuca, A. Adem, M. Y. B. Hasan, F. Hashemi, and K. Tekes

Summary

HPLC monitoring of pharmacokinetics was done in two body compartments of rats following intramuscular treatments with three different doses of K027, a bispyridinium mono-aldoxime type of antidotes to organoposphate intoxicated subjects. Reversed-phase HPLC separation with electrochemical detections was done to monitor the onset, the maximum level, and offset in K027 concentration. Serum level of K027 showed a fast onset, independently from the doses of K027. Drug level in brain was showing an essentially delayed kinetics.

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Acta Chromatographica
Authors: Shuanghu Wang, Zixia Lin, Ke Su, Jing Zhang, Lijing Zhang, Zhimou Gao, Zhiyi Wang, Jianshe Ma, and Xianqin Wang

mL can result in human beings' moderately severe poisoning whose rate of death is as high as over 50% [ 5 , 6 ]. The research for the antidote to the paraquat is of great importance. As non-selective herbicide, it has been applied to agriculture in

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typically used clinically as an antidote to treat patients poisoned by ARs, subsequent to accidental or intended exposures (i.e., suicide attempts, or poisoning of others [ 3 ]. In this context, a rapid analytical method would be invaluable to confirm a

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