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.5 µmol/L concentration for 3 h. Fig. 1. The chemical structures of quercetin (Que) and deoxynivalenol (DON) It is extremely challenging to provide mycotoxin-free feedstuffs for livestock. Pigs are very sensitive to mycotoxin-contaminated feeds ( Diekman

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Acta Veterinaria Hungarica
Authors: Csilla Pelyhe, Benjámin Kövesi, Erika Zándoki, Balázs Kovács, Judit Szabó-Fodor, Miklós Mézes, and Krisztián Balogh

. M. , Elmor , A. E. H. I. , Encarnação , P. and Bureau , D. P. ( 2011 ): Rainbow trout ( Oncorhynchus mykiss ) is extremely sensitive to the feed-borne Fusarium mycotoxin deoxynivalenol (DON) . Aquaculture 311 , 224 – 232

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Acta Veterinaria Hungarica
Authors: Mangesh Nakade, Csilla Pelyhe, Benjámin Kövesi, Krisztián Balogh, Balázs Kovács, Judit Szabó-Fodor, Erika Zándoki, Miklós Mézes, and Márta Erdélyi

References 2006/576/EC ( 2006 ): Commission Recommendation on the presence of deoxynivalenol, zearalenone, ochratoxin A, T-2 and HT-2 and fumonisins in products intended for animal feeding

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Acta Veterinaria Hungarica
Authors: Mariam Kachlek, Judit Szabó-Fodor, Zsófia Blochné Bodnár, Katalin Horvatovich, and Melinda Kovács

. Alassane-Kpembi , I. , Puel , O. and Oswald , I. P. ( 2015 ): Toxicological interactions between the mycotoxins deoxynivalenol, nivalenol and their acetylated derivatives in intestinal epithelial cells . Arch. Toxicol. 89 , 1337 – 1346

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55 463 470 Bergsjø, B., Langseth, W., Nafstad, I., Jansen, J. H. and Larsen, H. J. S. (1993): The effects of naturally deoxynivalenol

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Acta Veterinaria Hungarica
Authors: Viera Revajová, Mikuláš Levkut, Mária Levkutová, Radka Bořutová, Ľubomíra Grešaková, Božena Košiková, and Ľubomír Leng

Awad, W. A., Ghareeb, K., Bohm, J., Razzazi, E., Hellweg, P. and Zentek, J. (2008): The impact of the Fusarium toxin deoxynivalenol (DON) on poultry. Int. J. Poult. Sci. 7 , 827

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We examined the blastogenic response to phytohaemaglutinin (PHA) in HLA-B8, DR3 positive and negative subjects in the presence or absence of the immunosuppressive Fusarium mycotoxin.  HLA-B8, DR3 haplotype was associated with a depression of the response to mitogen in the absence of the mycotoxin, whereas in the presence of deoxynivalenol we could not detect significant differences among individuals either possessing or lacking this haplotype.

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The mycotoxins β-zearalenol (β-ZOL) and deoxynivalenol (DON) produce toxic effects that result in diseases in humans and animals. The molecular mechanisms that control the mycotoxin-mediated effects are far from being completely understood. Various results show that these mycotoxins could inhibit cell proliferation. In the present short communication, the influence of β-ZOL and DON on the abundance and phosphorylation state of kinases that are included in regulation of the initiation of mRNA translation (which is correlated with cell proliferation) was compared in porcine endometrial cells (PEC). Our results indicate that these mycotoxins modulate the expression and phosphorylation of these factors in a different manner. Whereas β-ZOL mainly had an impact on the biological activity of the extracellular signal-regulated protein kinases 1 and 2 (ERK1/2), protein kinase B (Akt), eukaryotic initiation factor 4E (eIF4E) and its repressor 4E binding protein 1 (4E-BP1), DON reduced the abundance of p38 MAPk, Akt and specific 4E-BP1 bands. In summary, these results indicate that β-ZOL influences molecular events that are included in the initiation of mRNA translation in the porcine endometrium but DON does not alter such processes clearly.

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four groups based on their characteristic functional groups ( Biro, 2003 ). Deoxynivalenol (DON) is a mycotoxin classified as a type B trichothecene. Recent surveys have indicated that more than 50% of different cereal samples were positive for DON

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Acta Veterinaria Hungarica
Authors: András Szabó, Judit Szabó-Fodor, Hedvig Fébel, Miklós Mézes, Imre Repa, and Melinda Kovács

subchronic exposure of three Fusarium toxins (fumonisin B, deoxynivalenol and zearalenone) in rabbit bucks . J. Clin. Toxicol. 5 , 264 . doi:10.4172/2161-0495.1000264. Tirosh , O

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