Authors:G. Sohár, E. Pallagi, P. Szabó-Révész, and K. Tóth
Osteoarthritis, although classically conceived of as a degenerative consequence of aging, is a disease with an increasingly
well-characterized molecular pathophysiology. Pathologic changes in cartilage composition and molecular organization, as well
as elevated water content, alter the exquisite balance of biomechanical properties. Much of what is known about changes in
the extracellular matrix in osteoarthritis comes from animal models.
Previously, thermogravimetric methods have not been used for compositional thermoanalytical study of normal and degenerative
human hyaline cartilage. For this reason the research group established a sufficient new thermogravimetric protocol, which
proved water content elevation contributing to disease progression.
Authors:Z. Aigner, L. Mécs, G. Sohár, K. Wellinger, Piroska Szabó-Révész, and K. Tóth
The purpose of this investigation was to further elucidate calorimetric properties of cartilage samples from femoral head
necrosis and osteoarthritis from live surgeries. The natural course of this disease is one of steady progression with eventual
collapse of the femoral head, followed by secondary osteoarthritis in the hip joint. All samples showed a clear denaturation
peak on the calorimetric curve. Cartilage obtained from necrotic femoral head required the lowest amount of energy for decomposition.
The use differential scanning calorimetry as part of thermal analysis was a reliable method for differentiating.
Arthritis of major joints, especially osteoarthritis of the knee is a very frequent disease of human beings mainly in the
developed countries. The pathology of osteoarthritis has been subject of many publications before, using a wide spectrum of
different methods to evaluate degenerative changes of hyaline cartilage. The authors examined osteoarthritic human knee joint
hyaline cartilage with differential scanning calorimetry. The different stages of cartilage degeneration have been verified
by histological examinations. The research group demonstrated thermal differences between various stages of osteoarthritis.
Besides explaining possible causes for experienced thermodynamic effects, the authors reflect upon future research ways and
the possibilities of applying the method in practice.
Authors:L. Mécs, Z. Aigner, G. Sohár, Piroska Szabó-Révész, and K. Tóth
The purpose of this study was to further characterize the altered metabolism spondylolisthesis that promotes disease progression.
Degenerative human cartilage (intervertebral disc, facet joint and vertebral end-plate) was obtained during 15 posterior lumbar
spine interbody fusion procedures performed at the University of Szeged. The thermal properties of samples were determined
by differential scanning calorimetry (Mettler-Toledo DSC 821e). Greatest change in the enthalpy was observed in the intervertebral disc samples: −1600.78 J g−1. Denaturation caused by heating in the normal human hyaline cartilage needed −1493.31 J g−1 energy. Characterization of the altered metabolism that promotes disease progression should lead to future treatment options.
Authors:J. Csotye, Z. Aigner, G. Sohár, Piroska Szabó-Révész, and K. Tóth
The glenohumeral joint is not a classical mass bearing joint, the treatment of primary osteoarthritis is conservative. In
all other cases, when the arthritis is associated with unbalance of the soft tissues, the treatment solution of this pathology
is arthroplasty. The purpose of this study was to examine the altered metabolism in human degenerated cartilage of the shoulder
joint. With the rise of temperature an endothermic reaction was observed in all cases. The use differential scanning calorimetry
as part of thermal analysis was a reliable method for differentiating normal hyaline cartilage from degenerated samples.
Authors:K. Tóth, G. Sohár, Z. Aigner, F. Greksa, and Piroska Szabó-Révész
During recent years, knowledge of rheumatoid arthritis has increased, and management of the disease has improved. A limited
number of papers have been published before on the subject of thermal analysis of degenerative cartilage but rheumatoid arthritis
(RA) has not been studied previously. A new protocol had to be established before the investigation. The purpose of this study
was to further characterize the altered metabolism in human RA cartilage that promotes disease progression.
Previously, these methods have not been used for this purpose. The use of thermal analysis could be an effective method for
controlling the relationship between biomarkers and disease progression.
Authors:I. Naumov, D. Lőrinczy, L. Vámhidy, P. Than, and N. Wiegand
Sohár , G , Pallagi , E , Szabó-Révész , P , Tóth , K 2007 New thermogravimetric protocol for the investigation of normal and damaged humanhyalinecartilage . J Thermal Anal Calorim 89 : 853 – 856 10.1007/s10973
Authors:K. S. Pramod, V. Vijayasundaram, N. Krishnakumar, and PL. RM. Palaniappan
Sohar , G , Pallagi , E , Szabo-Revesz , P , Toth , K . New thermogravimetric protocol for the investigation of normal and damaged humanhyalinecartilage . J Therm Anal Calorim . 2007 ; 89 : 853 – 856 . 10.1007/s10973