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Amyotrophic lateral sclerosis (ALS) is a devastating neurological disorder affecting upper and lower motoneurons. Since immune disbalance is known to be an important manifestation of the disease, working with the familial ALS rat model, hSODG93A (containing multiple copies of the human SOD1 G93A mutation), we were particularly interested in following by live magnetic resonance imaging (MRI) the immune cells labeled by ultra small paramagnetic iron oxide (USPIO) nanoparticles. In addition, microglial activation was studied by immunocytochemistry. MRI of USPIO labeled Tcells revealed CD4+ lymphocyte infiltration in the midbraininterbrain region while the CD8+ cells were more confined to the brainstem region. By way of gadolinium (Gd) contrast it was also confirmed that the bloodbrain barrier (BBB) was compromised. Moreover, it was revealed that the regions of BBB breakthrough were congruent with the MRI foci of Tcell infiltration. Immunocytochemistry revealed microglial activation and fusion, possibly phagocytic interactions with neurons in the hippocampus and brainstem. These observations prove the existence of an elaborate inflammatory process in the brain of hSODG93A rats, and also demonstrates the complexity and multifocality of ALS as having its inflammatory manifestations also in the central nervous system (hippocampus) distinct from clinically described motor foci of degeneration.

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Thill M, Kurylcio A, Welter R, van Haasteren V, Grosse B, Berclaz G, Polkowski W, Hauser N: The Central-European SentiMag study: sentinel lymph node biopsy with superparamagnetic iron oxide (SPIO) vs

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Orvosi Hetilap
Authors: , Budapest, Üllői út 78., 1082, Csilla András, Péter Bartek, István Battyáni, János Bezsilla, György Bodoky, Barna Bogner, Attila Bursics, Tibor Csőszi, László Damjanovich, Magdolna Dank, Zsófia Dankovics, Pál Ákos Deák, Kristóf Dede, Attila Doros, Ibolyka Dudás, Tamás Györke, Oszkár Hahn, Erika Hartmann, Erika Hitre, Zsolt Horváth, Marianna Imre, Károly Kalmár Nagy, Zsolt Káposztás, László Kóbori, Péter Kupcsulik, László Landherr, Zoltán Lóderer, László Mangel, Zoltán Máthé, Tamás Mersich, Klára Mezei, Elemér Mohos, Attila Oláh, Péter Pajor, András Palkó, Zsuzsanna Pápai, András Papp, Mihály Patyánik, András Petri, János Révész, Ágnes Ruzsa, Krisztina Schlachter, László Sikorszki, István Sipőcz, Eszter Székely, Attila Szijártó, László Torday, Lajos Barna Tóth, Edit Dósa, László Harsányi, Gábor István, László Landherr, György Lázár, József Lövey, Zsuzsa Schaff, Ákos Szűcs, and András Vereczkei

Cancer 2007; 96: 1037–1042. 124 Ward J, Guthrie JA, Sheridan MB, et al. Sinusoidal obstructive syndrome diagnosed with superparamagnetic iron oxide – Enhanced magnetic

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38 45 Muldoon, L. L., Manninger, S., Pinkston, K. E. és mtsai: Imaging, distribution and toxicity of iron oxide magnetic resonance agents in rat brain and

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Acta Physiologica Hungarica
Authors: Teodora Mocan, S. Clichici, L. Agoşton-Coldea, L. Mocan, Ş Şimon, I. Ilie, A. Biriş, and Adriana Mureşan

Apopa P, Qian Y, Shao R, Guo NL, Schwegler-Berry D, Pacurari M, Porter D, Shi X, Vallyathan V, Flynn D: Iron oxide nanoparticles induce human microvascular endothelial cell permeability through reactive oxygen

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Acta Microbiologica et Immunologica Hungarica
Authors: Tamás Gáll, Gábor Lehoczki, Gyöngyi Gyémánt, Tamás Emri, Zsuzsa M. Szigeti, György Balla, József Balla, and István Pócsi

in patients with asymptomatic carotid stenosis undergoing coronary artery bypass grafting: An ultrasmall superparamagnetic iron oxide enhanced magnet . Eur J Vasc Endovasc Surg 35 , 392 – 398 ( 2008 ). 10.1016/j.ejvs.2007

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Interventional Medicine and Applied Science
Authors: Anand Maurya, Anurag Kumar Singh, Gaurav Mishra, Komal Kumari, Arati Rai, Bhupesh Sharma, Giriraj T. Kulkarni, and Rajendra Awasthi

Active constituents Therapeutic use Name of company Silicon-coated iron oxide Ferumoxsil

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